Ancillary Studies to Identify Behavioral and/or Psychological Phenotypes Contributing to Obesity (R01 Clinical Trial Optional)

Funding Opportunity PAR-18-105 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage grant applications to support the addition of measures of psychological and/or behavioral constructs or weight-related variables (e.g.; BMI, body composition) to existing or new research studies in humans with the goal of elucidating behavioral or psychological phenotypes that explain individual variability in weight trajectory or response to obesity prevention or treatment interventions. The intent is to support the addition of new measurement in domains other than those covered in the parent grant as a means of elucidating the behavioral and psychological factors that may explain individual differences in weight status. For the purposes of this FOA, behavioral factors related to energy intake include overt actions/behavior (e.g.; objective observation of eating event including measures such as quantity, selection/quality, and speed of intake) and underlying psychological processes related to self-regulation of intake such as cognitive control, affective response, learning, and motivation. The rationale is that an improved understanding of the individual characteristics and processes that explain energy intake patterns can lead to better matching of individuals to prevention or treatment approaches and identify novel targets for more efficacious individual and population level approaches to weight management.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

Related Links:

ConclusionWe present a comprehensive mRNA expression profile of chromogranin A positive enteroendocrine cells following RYGB in rats. The data provides a region-specific characterization of all regulated preprohormone encoding genes in the rat GI tract including 16 not hitherto known. The comprehensive catalogue of preprohormone expression changes may support our understanding of hormone mediated effects of RYGB on diabetes remission and body weight reduction.Graphical abstract
Source: Peptides - Category: Biochemistry Source Type: research
Abstract The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not known. In contrast, mechanistic understanding of other brain disorders including neurodegeneration has advanced considerably. Yet, these do not approach the knowledge accrued for many cancers with precision therapeutics acting on well-characterized targets. Although the identification of genes responsible for neurodevelopmental and neuropsychiatric disorders remains a major obstacle, the few causally associated genes are ripe for discovery by focusing efforts to dissect their mechanisms. Here, we make a case for del...
Source: CNS Neuroscience and Therapeutics - Category: Neuroscience Authors: Tags: CNS Neurosci Ther Source Type: research
Publication date: Available online 15 June 2019Source: Science &SportsAuthor(s): J. Zhao, J. Shi, B. Wu, X. Bai, H. DuSummaryIntroductionThe aim of this study was to determine the effects of aerobic exercise on the alternative splicing of PKCδI pre-mRNA in obese mice.Summary of facts and resultsAfter aerobic exercise, the weight, the Lee's index and the blood lipid levels of obese mice decreased significantly (P 
Source: Science and Sports - Category: Sports Medicine Source Type: research
ConclusionThese findings indicate that the HFS Weanling group animals were better able to cope with the dietary challenge of an HFS diet than the HFS Adult group animals. Interestingly, when assessing various serum pro-inflammatory markers, no significant differences were detected between the HFS Adult and HFS Weanling groups. Although details regarding the mechanisms underlying an increase in knee joint damage scores in the HFS Adult group remain to be elucidated, these findings indicate that dietary exposure time maybe less important than the age at which a HFS diet is introduced. Moreover, increases in serum pro-inflamm...
Source: Journal of Sport and Health Science - Category: Sports Medicine Source Type: research
It is estimated that 2.5 million emergency department (ED) visits annually in the United States are attributed to sports-related knee injuries.1 An additional 184,000 ED visits in the United States each year are attributed to occupational knee injuries.2 About 25% of adults older than 55 years suffer from chronic knee pain, an increasing prevalence due to an aging population and increased prevalence of obesity.3
Source: Contemporary Diagnostic Radiology - Category: Radiology Tags: ARTICLE Source Type: research
In this study, analysis of antioxidant defense was performed on the blood samples from 184 "aged" individuals aged 65-90+ years, and compared to the blood samples of 37 individuals just about at the beginning of aging, aged 55-59 years. Statistically significant decreases of Zn,Cu-superoxide dismutase (SOD-1), catalase (CAT), and glutathione peroxidase (GSH-Px) activities were observed in elderly people in comparison with the control group. Moreover, an inverse correlation between the activities of SOD-1, CAT, and GSH-Px and the age of the examined persons was found. No age-related changes in glutathione reductas...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, predictors of LOS were identified using a survival model that considered age as a continuous variable, separate comorbidities, and the discharge destination. Our findings are consistent with earlier reports and confirm the strong associations linking LOS to diabetes, day of surgery, and discharge destination in France. We also identified predictors of discharge to rehabilitation and of readmission within 30 days.Level of evidenceIV, retrospective observational cohort study.
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
ius The effectiveness of an individual six-month-long physical exercise program in improving health-related quality of life (HRQOL) is unclear. There is some evidence that an individual exercise program can be effective for this aim. The goal of this study was to compare an individual six-month-long physical exercise program for patients with PAD (Peripheral Arterial Disease) with a traditional exercise program and find the effect of these programs on HRQOL and PAD risk factors. The study included patients who underwent femoral–popliteal artery bypass grafting surgery. Patients were divided into three groups:...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Publication date: August 2019Source: Molecular Immunology, Volume 112Author(s): Elizabeth A. Bemis, Jill M. Norris, Jennifer Seifert, Ashley Frazer-Abel, Yuko Okamoto, Marie L. Feser, M. Kristen Demoruelle, Kevin D. Deane, Nirmal K. Banda, V. Michael HolersAbstractRheumatoid arthritis (RA) is a complex autoimmune disease with an etiology that is not yet well understood, disproportionally affects women and also varies in incidence and prevalence by population. The presence of anti-citrullinated protein antibodies (ACPA) is a highly specific biomarker for the diagnosis of clinically apparent RA. ACPA are also present in the ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Abstract Although the life-course concept of risk markers as potential etiological influences is well established in epidemiology, it has not featured in academic publications or clinical practice in the context of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS). Studies of risk markers are required considerations for evaluation of patients and for research because there is no single cause, pathological feature, laboratory finding, or biomarker for CWP or FMS. The early-life risk markers identified by extensive literature review with best evidence for potential causal influence on the development and...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
More News: Clinical Trials | Contracts | Eating Disorders & Weight Management | Funding | Grants | Learning | Obesity | Psychology | Research | Study | Universities & Medical Training