Endoplasmic reticulum in health and disease: the 12th International Calreticulin Workshop, Delphi, Greece
Abstract Starting from 1994, every 2 years, an international workshop is organized focused on calreticulin and other endoplasmic reticulum chaperones. In 2017, the workshop took place at Delphi Greece. Participants from North and South America, Europe, Asia and Australia presented their recent data and discussed them extensively with their colleagues. Presentations dealt with structural aspects of calreticulin and calnexin, the role of Ca2+ in cellular signalling and in autophagy, the endoplasmic reticulum stress and the unfolded protein response, the role of calreticulin in immune responses. Several presentations focused on the role of calreticulin and other ER chaperones in a variety of disease states, including haemophilia, obesity, diabetes, Sjogren's syndrome, Chagas diseases, multiple sclerosis, amyotrophic lateral sclerosis, neurological malignancies (especially glioblastoma), haematological malignancies (especially essential thrombocythemia and myelofibrosis), lung adenocarcinoma, renal pathology with emphasis in fibrosis and drug toxicity. In addition, the role of calreticulin and calnexin in growth and wound healing was discussed, as well as the possible use of extracellular calreticulin as a marker for certain diseases. It was agreed that the 13th International Calreticulin Workshop will be organized in 2019 in Montreal, Quebec, Canada.
DIABETES type 2 symptoms include increased thirst, unexplained weight loss and frequently needing the toilet. Diabetes type 2 develops later in life due to risk factors including being overweight and having high blood pressure. New research has shown that eating in a 6-hour time period can prevent the condition.
Authors: Honore T, Le Breton F, Turmel N, Bignani B, Chesnel C, Charlanes A, Amarenco G Abstract PURPOSE: To evaluate safety and efficacy of botulinum toxin A injections in the urethral striated sphincter in patients with difficulties to perform self-intermittent catherization. METHODS: In this prospective study, 12 patients suffering from upper motor neuron diseases (8 multiple sclerosis, 2 myelitis, 1 brain injury, 1 multi system atrophy) and with difficulties to perform self-intermittent catherization, defined by a ICDQ score>1 (Intermittent Catheterization Difficulty Questionnair...
This study hypothesizes that being either underweight or obese is associated with a higher hospitalization rate. Observational study of 6296 European haemodialysis patients with prospective data collection and follow-up every six months for three years (COSMOS study). The risk of being hospitalized was estimated by a time-dependent Cox regression model and the annual risk (incidence rate ratios, IRR) by Poisson regression. We considered weight loss, weight gain and stable weight. Weight change analyses were also performed after patient stratification according to their baseline BMI. A total of 3096 patients were hospitaliz...
Conclusion: The proposed simulator can be used to perform credible ISCT in realistic insulin treatment scenarios. Significance: The T1D patient decision simulator can be used to reliably assess novel insulin treatmen- s, e.g., based on use of CGM only, in a realistic multiple-day scenario.
People with diabetes mellitus need annual screening to check for the development of diabetic retinopathy (DR). Tracking small retinal changes due to early diabetic retinopathy lesions in longitudinal fundus image sets is challenging due to intra- and intervisit variability in illumination and image quality, the required high registration accuracy, and the subtle appearance of retinal lesions compared to other retinal features. This paper presents a robust and flexible approach for automated detection of longitudinal retinal changes due to small red lesions by exploiting normalized fundus images that significantly reduce il...
Is the short synacthen test a reliable means of assessing HPA axis recovery after long-term glucocorticoid treatment?Endocrine Practice
Are adults with arthritis and who are overweight or obese receiving adequate weight loss counseling?Morbidity &Mortality Weekly Report
Contributors : Kathryn Miranda ; Prakash Nagarkatti ; Mitzi NagarkattiSeries Type : Non-coding RNA profiling by arrayOrganism : Mus musculus ; synthetic constructWe used microRNA microarrays to identify dysregulated microRNAs in macrophages isolated from adipose tissue of lean and obese mice.
Contributors : Kathryn Miranda ; Prakash Nagarkatti ; Mitzi NagarkattiSeries Type : Expression profiling by arrayOrganism : Mus musculusWe used transcriptome microarrays to identify gene expression changes in macrophages isolated from adipose tissue of lean and obese mice.
Authors: Yasemin C, Turan S, Kosan Z Abstract It was aimed to observe the efficacy of body acupuncture and auricular acupuncture for the management of obesity. Fifty female obese patients were randomized into 2 groups; a Body Acupuncture Group (GBA; n=25) and an Auricular Acupuncture Group (GAA; n=25). All patients were followed up for 12 weeks. Their anthropometric measurements (body weight, body mass index, body fat percentage, waist circumference and hip circumference) were recorded for analysis in every 15 days. Patients were compared in terms of anthropometric measurements. Patients in the GAA received 6 sessi...
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