TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis

In this report, we show that TSPO deletion mutations in rat and its corresponding rs6971 polymorphism in humans alter adrenocorticotropic hormone-induced plasma corticosteroid concentrations. Rat tissues examined show increased cholesteryl ester accumulation, and neurosteroid formation was undetectable in homozygous rats. These results also support a role for TSPO ligands in diseases with steroid-dependent stress and anxiety elements.
Source: Biochemical Journal - Category: Biochemistry Authors: Tags: Research Articles Source Type: research