TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis
In this report, we show that TSPO deletion mutations in rat and its corresponding rs6971 polymorphism in humans alter adrenocorticotropic hormone-induced plasma corticosteroid concentrations. Rat tissues examined show increased cholesteryl ester accumulation, and neurosteroid formation was undetectable in homozygous rats. These results also support a role for TSPO ligands in diseases with steroid-dependent stress and anxiety elements.
Source: Biochemical Journal - Category: Biochemistry Authors: Owen, D. R., Fan, J., Campioli, E., Venugopal, S., Midzak, A., Daly, E., Harlay, A., Issop, L., Libri, V., Kalogiannopoulou, D., Oliver, E., Gallego-Colon, E., Colasanti, A., Huson, L., Rabiner, E. A., Suppiah, P., Essagian, C., Matthews, P. M., Papadopou Tags: Research Articles Source Type: research
More News: Anxiety | Biochemistry | Brain | Cholesterol | Corticosteroid Therapy | Genetics | Hormones | Mitochondria | Mitochondrial Disease | Neurology