Metabotropic Glutamate Receptor 2/3 as Targets for Treating Nicotine Addiction

Tobacco smoking, driven by the addictive properties of nicotine, continues to be a worldwide health problem. Based on the well-established role of glutamatergic neurotransmission in drug addiction, novel medication development strategies seek to halt nicotine consumption and prevent relapse to tobacco smoking by modulating glutamate transmission. The presynaptic inhibitory metabotropic glutamate receptors (mGluR) 2/3 are key autoreceptors on glutamatergic terminals that maintain glutamate homeostasis.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research