Neocortical origin and progression of grey matter atrophy in non-amnestic Alzheimer's disease

We examined spreading disease in non-amnestic Alzheimer's disease using a novel magnetic resonance imaging-based analysis adapted from pathologic staging studies, applied here to cross-sectional imaging data. We selected 240 T1-weighted scans from 129 patients with pathology confirmed by autopsy or cerebrospinal fluid, and atrophy maps were computed relative to 238 scans from 115 elderly controls.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Source Type: research