Neocortical origin and progression of grey matter atrophy in non-amnestic Alzheimer's disease
We examined spreading disease in non-amnestic Alzheimer's disease using a novel magnetic resonance imaging-based analysis adapted from pathologic staging studies, applied here to cross-sectional imaging data. We selected 240 T1-weighted scans from 129 patients with pathology confirmed by autopsy or cerebrospinal fluid, and atrophy maps were computed relative to 238 scans from 115 elderly controls.
Source: Neurobiology of Aging - Category: Neuroscience Authors: Jeffrey S. Phillips, Fulvio Da Re, Laynie Dratch, Sharon X. Xie, David J. Irwin, Corey T. McMillan, Sanjeev N. Vaishnavi, Carlo Ferrarese, Edward B. Lee, Leslie M. Shaw, John Q. Trojanowski, David A. Wolk, Murray Grossman Source Type: research