Novel idiopathic DCM-related SCN5A variants localised in DI-S4 predispose electrical disorders by reducing peak sodium current density

Conclusion
Our results suggest that the iDCM-related SCN5A variants in the DI-S4 could predispose electrical disorders by reducing peak sodium current density.

Source: Journal of Medical Genetics - October 23, 2017 Category: Genetics & Stem Cells Authors: Shen, C., Xu, L., Han, S., Dong, Z., Zhao, X., Wang, S., Qian, S., Li, B., Ma, X., Wang, P., Zhu, H., Zou, Y., Fan, Z., Ge, J., Sun, A. Tags: Genotype-phenotype correlations Source Type: research