A pilot resting-state functional connectivity study of the kynurenine pathway in adolescents with depression and healthy controls

The neuroimmunological kynurenine pathway (KP) has been hypothesized to play a role in depressive/anhedonic symptoms and related CNS disturbances. Indoleamine 2,3-dioxygenase (IDO) is the rate limiting enzyme which leads to neurotrophic [kynurenic acid (KA)] and neurotoxic [Quinolinic acid (QUIN)] branches. In this pilot, we sought to examine associations between blood KP neuro-toxic/trophic measures and anhedonia/depression associated network in youth with major depression (MDD) and healthy controls (HC).
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research