Semilobar Holoprosencephaly Identified on Prenatal MRI

Members of the neurology service were asked to give an opinion on the prognosis of a child whose prenatal MRI showed holoprosencephaly (figure). The test was done as interpretation of the prenatal ultrasound at 27 weeks of gestation was concerning for abnormal brain development. The post-natal MRI confirmed the diagnosis of semilobar holoprosencephaly. At birth, the child was deemed to be small for gestational age, she had evident cleft lip and palate, hypertelorism, and microphthalmia. She was later diagnosed with panhypopituitarism and epilepsy.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Visual Diagnosis Source Type: research