Letter re: Dementia risk in renal dysfunction: A systematic review and meta-analysis of prospective studies

Deckers et al.1 conducted random effects meta-analyses on the prospective association between potential markers of renal dysfunction and development of cognitive impairment or dementia. Pooled odds ratios (95% confidence intervals) of albuminuria and estimated glomerular filtration rate <60 mL/min/1.73 m2 for cognitive impairment or dementia were 1.35 (1.06–1.73) and 1.28 (0.99–1.65), respectively.1 As the number of studies was not sufficient, meta-analyses could not be done for serum creatinine, creatinine clearance, or cystatin C.1 The authors concluded that albuminuria was a useful marker of renal dysfunction for screening the development of cognitive impairment or dementia.1 I have 2 concerns about their study.

Source: Neurology - November 20, 2017 Category: Neurology Authors: Kawada, T. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research