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Spaceflight-induced changes in white matter hyperintensity burden in astronauts

Conclusions: Long-duration exposure to microgravity is associated with an increase in periventricular WMH in astronauts. This increase was linked to an increase in ventricular CSF volume documented in ISS astronauts. There was no associated change in or abnormal levels of WMH volumes in deep white matter as reported in U-2 high-altitude pilots.
Source: Neurology - Category: Neurology Authors: Tags: MRI, Volumetric MRI, Case control studies ARTICLE Source Type: research

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In this study, nanostructured lipid carriers (NLCs) of ND are developed to enhance the oral bioavailability. ND-NLCs were prepared using hot homogenization-ultrasonication method, using oleic acid and trimyristate as liquid lipid and solid lipid, respectively. Prepared NLCs are evaluated for an optimal system using measuring size, zeta potential, entrapment efficiency, in-vitro release and in-situ absorption studies. Further, in vivo pharmacokinetic (PK) studies of NLC were conducted in rats comparison with SLN and suspension as controls. Size, ZP and EE of optimized NLCs were found to be 110.4 ± 2.95&...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Conclusion: Vessel density measurements showed good repeatability and reproducibility by OCT-A in the peripapillary retina, the vessel density was positively related to RNFL thickness and negatively related to optic disc area and rim area.Ophthalmologica
Source: Ophthalmologica - Category: Opthalmology Source Type: research
Authors: Terasaki F, Fujita SI, Kanzaki Y, Hirose Y, Ishizaka N Abstract Fluorine-18 fluorodeoxygluose (18F-FDG) positron emission tomography (PET) is a useful tool for evaluating disease activity in sarcoidosis including cardiac involvement. A 67-year-old patient who developed atrioventricular block requiring permanent pacemaker implantation was diagnosed with cardiac sarcoidosis. The patient did not undergo steroid or immunosuppressive therapy but underwent serial 18F-FDG PET examination, which showed spontaneous reduction in the myocardial FDG uptake, indicating the remission of immune-inflammatory activity. Alt...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Shares in Natus Medical (Nasdaq: BABY) fell today after the newborn-focused medical device maker posted first quarter earnings that saw profits turn to losses, despite topping Wall Street expectations for sales and earnings per share. The Pleasanton, Calif.-based company posted losses of approximately $3.2 million, or 10¢ per share, on sales of $128.6 million for the three months ended March 31, seeing a massive swing from profits on the bottom-line while sales grew 3.2% compared with the same period during the previous year. After adjusting for one-time items, earnings per share were 24¢, just in line ...
Source: Mass Device - Category: Medical Devices Authors: Tags: Business/Financial News MassDevice Earnings Roundup Wall Street Beat Natus Medical Inc. Source Type: news
CONCLUSION: Danish occupational therapists perceive to practice CCP and appear to have adopted the beliefs, theory and ideals of CCP, perhaps influenced by the egalitarian Danish culture. Self-directed work, means to identify and evaluate their clients' wishes, and education facilitated CCP. Possible absence of occupational therapists not compliant with CCP makes further research warranted. PMID: 29681211 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
___ Time for SharpBrains eNewsletter, bringing you the latest in in brain health and mental health research, tools and thinking. Also, a quick heads-up for those based in the UK: the Imperial College Centre for Neurotechnology will host a keynote by Alvaro Fernandez in London on Wednesday, May 30th, titled Why the Future of Brain Enhancement & Mental Health is Digital & Pervasive (free; requires registration). Other upcoming events here. New research: Study finds continued birth of new neurons (neurogenesis) well into our 70s The more hours you sit per day, the smaller your med...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology app brain Brain-health brain-scans brain-stimulation Brainnovations Cognitive-Training meditation Mental-Health Neurogenesis Neurotechnology smartphone Source Type: blogs
Conclusions: IVCM demonstrated dramatic damage to subbasal corneal nerves after brief UV-C exposure. The patient, treated with autologous serum eye drops in both eyes, achieved resolution of symptoms and recovery of subbasal corneal nerves. PMID: 29682341 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Is this a model for pain medicine to emulate? An E.R. That Treats You Like a V.I.P. "The facility, Priority Private Care, administered a CT scan and read the results on the spot. Mr. Wilson’s wife was fine, and they went home. “I was out of there in 40 minutes,” he said. For such service, he pays $10,000 a year. The fee covers concierge emergency... Concierge ED's...
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums
We report here the prognostic value of early metabolic response by 18F-FDG PET scanner (PET) in 25 newly diagnosed immunocompetent PCNSL patients. Induction treatment consisted of four cycles of Rituximab, Methotrexate and Temozolamide (RMT). Based on patient's general condition, consolidation by high-dose Etoposide and Aracytine was given to responding patients. Brain MRI and PET were performed at diagnosis, after two and four cycles of RMT, and after treatment completion. Two-year progression-free (PFS) and overall survival (OS) were 62% and 74%, respectively for the whole cohort. Best responses after RMT induction were ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusions: Extra-focal percutaneous valgus lateral translation osteotomy and fixation with a low-profile Ilizarov frame allows accurate deformity correction, shorter duration in the fixator, and better patient comfort and satisfaction.
Source: Current Orthopaedic Practice - Category: Orthopaedics Tags: Original Research Source Type: research
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