Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration

Objectives: To investigate whether serum neurofilament light (NfL) concentration is increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and whether it is associated with markers of disease stage and severity. Methods: We recruited 48 individuals from families with PSEN1 or APP mutations to a cross-sectional study: 18 had symptomatic Alzheimer disease (AD) and 30 were asymptomatic but at 50% risk of carrying a mutation. Serum NfL was measured using an ultrasensitive immunoassay on the single molecule array (Simoa) platform. Cognitive testing and MRI were performed; 33 participants had serial MRI, allowing calculation of atrophy rates. Genetic testing established mutation status. A generalized least squares regression model was used to compare serum NfL among symptomatic mutation carriers, presymptomatic carriers, and noncarriers, adjusting for age and sex. Spearman coefficients assessed associations between serum NfL and (1) estimated years to/from symptom onset (EYO), (2) cognitive measures, and (3) MRI measures of atrophy. Results: Nineteen of the asymptomatic participants were mutation carriers (mean EYO –9.6); 11 were noncarriers. Compared with noncarriers, serum NfL concentration was higher in both symptomatic (p
Source: Neurology - Category: Neurology Authors: Tags: Alzheimer's disease ARTICLE Source Type: research

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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Behind every good caregiving intention is usually a fair amount of love and caring.By Paula Spencer ScottAlzheimer's Reading RoomAre you sometimes nagged by the question,Am I getting this right?What is the Difference Between Alzheimer ’s and DementiaSubscribe to the Alzheimer's Reading RoomEmail:Few of us cast into the role of Alzheimer's caregiver have training or experience in dealing with the many difficult decision we face each day.Should Dad stay on the combination of Aricept and Namenda?Which child's house would be best for him to live in?Is it better for him if we don't bring him on vacation with us?Do we go a...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimers alzheimers quote care of dementia patient caregiving connectalzheimersdementia dementia nursing care health how to senior care Source Type: blogs
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Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
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Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
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Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Conditions:   Alzheimer's Disease;   Cortical Basal Syndrome;   Frontotemporal Dementia;   Progressive Supranuclear Palsy;   Vascular Cognitive Impairment Intervention:   Drug: F-18 Sponsor:   Chang Gung Memorial Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionQuantitative assessment of structural brain MRI combined with a reference standard in addition to standard visual assessment may improve diagnostic accuracy in a memory clinic setting.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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