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Serum neurofilament light in familial Alzheimer disease: A marker of early neurodegeneration

Objectives: To investigate whether serum neurofilament light (NfL) concentration is increased in familial Alzheimer disease (FAD), both pre and post symptom onset, and whether it is associated with markers of disease stage and severity. Methods: We recruited 48 individuals from families with PSEN1 or APP mutations to a cross-sectional study: 18 had symptomatic Alzheimer disease (AD) and 30 were asymptomatic but at 50% risk of carrying a mutation. Serum NfL was measured using an ultrasensitive immunoassay on the single molecule array (Simoa) platform. Cognitive testing and MRI were performed; 33 participants had serial MRI, allowing calculation of atrophy rates. Genetic testing established mutation status. A generalized least squares regression model was used to compare serum NfL among symptomatic mutation carriers, presymptomatic carriers, and noncarriers, adjusting for age and sex. Spearman coefficients assessed associations between serum NfL and (1) estimated years to/from symptom onset (EYO), (2) cognitive measures, and (3) MRI measures of atrophy. Results: Nineteen of the asymptomatic participants were mutation carriers (mean EYO –9.6); 11 were noncarriers. Compared with noncarriers, serum NfL concentration was higher in both symptomatic (p
Source: Neurology - Category: Neurology Authors: Tags: Alzheimer's disease ARTICLE Source Type: research

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One of the biggest issues we face as Alzheimer's caregivers is learning to understand how a person living with dementia thinks and feels, and why they act the way they do.Early on,many of us conclude that the person living with dementia is being mean to us.The changes that come with dementia can bedistressing to a caregiver.As caregivers we often feelangry, disconcerted and sometimes, we feela sense of heavy burden, hopelessness, and even heartbreak.What is The Difference Between Alzheimer's and DementiaBy Bob DeMarcoAlzheimer's Reading RoomSubscribe to the Alzheimer's Reading - This is a Free Service - Join NowAs caregive...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer communication alzheimers care alzheimers caregiving awareness dementia help for caregivers family caregiving help alzheimer's help with dementia help with dementia care Source Type: blogs
In a rare series of moves, Dutch authorities are investigating whether doctors may have committed crimes including murder or other offences in five euthanasia cases, including the deaths of two women with advanced Alzheimer's disease
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Many of us start our caregiving career by assisting an elder in his or her home, or we have a spouse who declines and we become the default caregiver in our own home. This care expands to a point where we need some type of respite, often in the form of in-home care agency help. Eventually, the move to assisted living or even a nursing home may become necessary for everyone's health and wellbeing. Whatever happens, we remain caregivers. Many of us continue to see our care receiver daily. Most of us continue to be involved as advocates and support throughout the time of need. When our loving attention and care is no longer n...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
The Lancet Commission (Dec 16, 2017, p 2673)1 on prevention and management of dementia reviews the mounting evidence that hearing loss is a major risk factor for cognitive decline. Crucial information is still absent about the nature of this linkage and what factors might modify the cognitive effect of peripheral hearing loss. Particularly, the potential relevance of central hearing impairment should not be underestimated. As Gill Livingston and colleagues1 acknowledge, on pathophysiological and neuroanatomical grounds, central auditory processing is likely to be susceptible early in the course of Alzheimer's disease and other dementias.
Source: LANCET - Category: General Medicine Authors: Tags: Correspondence Source Type: research
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Source: The Catalyst - Category: Pharmaceuticals Tags: Medicines in Development Research and Development Alzheimer's Source Type: news
The open access paper noted here reports on the use of a genetic analysis to shed further light on the relative importance of shared mechanisms across a range of neurodegenerative conditions in which tau aggregation is thought to be important. The researchers find associations in gene expression between these conditions that suggesting microglial dysfunction is an important common determinant of disease progression. If one looks over all of the most common neurodegenerative diseases, patients exhibit a number of overlapping mechanisms that appear plausible as proximate causes of brain cell dysfunction and death. Som...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
AbstractThe focus of modern biomedical research concentrates on molecular level regulatory mechanisms and how the normal and abnormal phenotypes of tissue functional are affected by regulatory mechanisms. Most of the research on regulatory mechanism starts from the reconstruction of gene regulation network. At present, a large number of reconstruction methods construct the network using a single data set. These methods of inferring and predicting the relationship between the target gene and the transcription factor (TF) can be used to identify individual interactions between genes, while there is not much research on the i...
Source: Interdisciplinary Sciences, Computational Life Sciences - Category: Bioinformatics Source Type: research
Szilvássy Z, Juhász B Abstract Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive impairment. Physical exercise has long been proven to be beneficial in the disorder. The present study was designed to examine the effect of voluntary exercise on spatial memory, imaging, and pathological abnormalities. Particular focus has been given to the role of heme oxygenase-1 (HO-1)-an important cellular cytoprotectant in preserving mental acuity-using an aging rat model of dementia. Male and female Wistar rats were segregated into six groups-namely, (i) aged sedentary (control) females (ASF,...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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Source: Folia Neuropathologica - Category: Pathology Authors: Tags: Folia Neuropathol Source Type: research
From our reader Judith:How do you get a urine sample from someone who doesn't understand what you're trying to do or resists the invasion of privacy?This is an excellent question and I have not written about this in some time. So here we go.Yes, getting a urine sample from a person living with dementia or an elderly person can be quite a task - sometimes near impossible.Well, I have a solution to this problem thatworks 100% of the time if the person can take a pee on a toilet.Did you know? An Undetected Urinary Tract Infection Can Kill an Alzheimer's Patientby Bob DeMarcoAlzheimer's Reading RoomSubscribe to the Alzheimer's...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: collecting a urine sample from a dementia patient how to get a urine sample from an elderly person urinary tract infection urine collection urine sample alzheimer urine sample dementia Source Type: blogs
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