Clinical Reasoning: An 82-year-old man with worsening gait

An 82-year-old man with hypothyroidism presented with difficulty walking.
Source: Neurology - Category: Neurology Authors: Tags: Autoimmune diseases, Gait disorders/ataxia, Stiff person syndrome RESIDENT AND FELLOW SECTION Source Type: research

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Anti‑osteopontin autoantibodies in various types of cancer. Oncol Rep. 2018 Oct 05;: Authors: Alsarkhi LK, Weber GF Abstract The aberrant processing of biomolecules by cancer cells may give rise to autoimmune phenomena. The metastasis gene osteopontin is alternatively spliced only in transformed cells, and the variants promote tumor progression. They may also serve as tumor‑associated antigens, and their neutralization by autoantibodies could favorably affect prognosis. A competitive solid‑phase ELISA format was applied to determine reactivity toward recombinant osteopontin in human serum or plas...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Qiu L, Zhou Y, Yu Q, Yu J, Li Q, Sun R Abstract Early stratification of the severity of acute pancreatitis (AP) is clinically important. Regulatory B cells have been found to be associated with disease activity of autoimmune diseases. However, the role of Regulatory B cells in AP remains unknown. We investigate the dynamic longitudinal changes in circulating IL-10-producing B cells (B10) and memory CD19+CD24hiCD27hi cells in patients with AP to evaluate their prediction utility for AP severity. B10, CD19+CD24hiCD27hi cells, inflammatory markers and cytokines were detected in patients with AP immediately af...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
AbstractThe distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadly studied for its attenuating effects on the human immune system. In an attempt to develop a novel therapeutic small molecule for the treatment of autoimmune conditions, we have conjugated PC with tuftsin, a natural immunomodulatory tetrapeptide, to create TPC. Herein, we review our findings regarding ...
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research
AbstractEBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human host including ZEBRA (BZLF-1 encoded protein), BALF-2 recombinase expressed primarily during the viral lytic replication cycle, and EBNA-1 (Epstein-Barr Virus Nuclear Antigen) expressed during the viral latency cycle respectively were characterized using a laser-printed micro-array (PEPperprint.com). IgG response to conserved “A/T hooks” in EBV-encoded ...
Source: Immunologic Research - Category: Allergy & Immunology Source Type: research
Conclusions: Childbirths and induced abortions may be followed by development of Graves ’ hyperthyroidism after the post-partum period. This was not the case for the non-autoimmune subtypes of hyperthyroidism.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research
Authors: Zhang Y, Wang Y, Tao XJ, Li Q, Li FF, Lee KO, Li DM, Ma JH Abstract Purpose: To determine if the TSH is related to estimated glomerular filtration rate (eGFR) in T2D patients without overt thyroid dysfunction. Methods: A cohort study of 5936 T2D patients was assessed for thyroid and kidney functions, in whom 248 with subclinical hyperthyroidism and 362 with subclinical hypothyroidism. Serum creatinine and 24-hour urine albumin excretion (UAE) were collected. Chronic kidney disease (CKD) was defined as eGFR 
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
ConclusionWe could not prove the presence of autonomic sympathetic dysfunction in our cohort of MG patients when assessed by Sudoscan®. In addition, Compass-31 was not a useful questionnaire in this clinical context.
Source: Neurophysiologie Clinique - Category: Neuroscience Source Type: research
This study was performed to establish trimester-specific reference ranges of thyroid hormones in Zhuang ethnic pregnant women and explore the role of body mass index (BMI) on thyroid function. A total of 3324 Zhuang ethnic health pregnant women were recruited in this Zhuang population-based retrospective cross-sectional study. The values of thyroid stimulating hormone (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) were determined by automatic chemiluminescence immunoassay analyzer. Multivariate linear regression and binary logistic regression were constructed to evaluate the influence of BMI on the thyroid fu...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
We present a case of declining cardiac function in a patient with Friedreich's Ataxia, however, her worsening cardiac function was not related to her chronic disease. Her declining cardiac function was associated with hypothyroidism that was initially overlooked. The purpose of this article is to remind physicians of the role that thyroid hormone has in cardiac function and overall health. Autoimmune hypothyroidism is a common condition, and physicians should consider screening thyroid function in any patient with poor or worsening cardiac function. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in ...
Source: Experimental and Clinical Endocrinology and Diabetes Reports - Category: Endocrinology Authors: Tags: Case Report Source Type: research
Ben shared his 3-week experience living the Wheat Belly lifestyle after being diagnosed with celiac disease: “My family doctor diagnosed me with celiac and wheat allergies. These pictures were taken 3 weeks apart: prior to the diagnosis and three weeks later, a photo of me after following the Wheat Belly books that my doctor recommended I get. “I still feel like I eat like a king. I am just a lot more cautious about what I put into my body and I am seeing the results!” You can see that Ben’s face shows the changes we expect to see as inflammation recedes: reduced cheek and around-the-eyes edema, la...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Success Stories celiac gluten grains Inflammation Source Type: blogs
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