The candidate schizophrenia risk gene DGCR2 regulates early steps of corticogenesis

Alterations in early steps of cortical circuit assembly are thought to play a critical role in vulnerability to schizophrenia (SZ), but the pathogenic impact of SZ-risk mutations on corticogenesis remains to be determined. DiGeorge Critical Region 2 (DGCR2) is located in the 22q11.2 locus, whose deletion is a major risk factor for SZ. Moreover, exome sequencing of individuals with idiopathic SZ identified a rare missense mutation in DGCR2, further suggesting that DGCR2 is involved in SZ.

Source: Biological Psychiatry - November 20, 2017 Category: Psychiatry Authors: Aude Molinard-Chenu, Alexandre Dayer Tags: Archival Report Source Type: research