Evaluation of Loopamp ™MTBC detection kit for diagnosis of pulmonary tuberculosis at a peripheral laboratory in a high burden setting

The Loopamp ™MTBC detection kit (TB-LAMP) was designed to replace the sputum smear microscopy for the diagnosis of pulmonary tuberculosis. We evaluated its performance at a peripheral laboratory in Vietnam. The sensitivity of TB-LAMP was 45.5% [28.1% - 63.6%], which was equal to three-sputum smear microscopy but lower than that of Xpert MTB/RIF (87.8% [71.8% - 96.6%]). In patients with culture-confirmed TB, sensitivity was 80% [51.9% - 95.7%] in smear-positive and 16.7% [3.5% - 41.4%] in smear-negative cases.

Source: Diagnostic Microbiology and Infectious Disease - November 20, 2017 Category: Microbiology Authors: Van Anh Thi Nguyen, Hung Van Nguyen, Thuong Van Dinh, Ha Hoang Du, Chinh Nhu Do, Guy B. Marks, Nhung Viet Nguyen Source Type: research