GI highlights from the literature

Basic scienceNod2: —a key component of the microbial intestinal crypt interface  Nigro G, Rossi R, Commere P-H, et al. The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration. Cell Host Microbe 15, 792–8. Genetic factors play an important role in the pathogenesis of Crohn's disease (CD). The most significant of these implicates aberrant immune responses central to microbial sensing/signalling and mucosa-initiated effector responses. Nucleotide oligomerisation domain 2 (Nod2) is a member of the Nod-like receptor (NLR) family of intracellular microbe sensors that are strongly involved in innate immunity. Nod2 is known to be expressed by paneth cells within intestinal crypts. However due to the complexity of this site in terms of the differing cell types present and the potential interactions with microbes, there has been debate as to the precise functions of each cell type. Nigro and colleagues used...
Source: Gut - Category: Gastroenterology Authors: Tags: JournalScan Source Type: research