In vitro infection of primary human hepatocytes by HCV-positive sera: insights on a highly relevant model

Conclusions
We identified critical factors leading to efficient PHH infection by HCV sera in vitro. Overall, we showed that this cellular model provides a useful tool for studying the mechanism of HCV infection in its natural host cell, selecting highly infectious isolates, and determining the potency of drugs towards various HCV strains.

Source: Gut - August 3, 2014 Category: Gastroenterology Authors: Gondeau, C., Briolotti, P., Razafy, F., Duret, C., Rubbo, P.-A., Helle, F., Reme, T., Ripault, M.-P., Ducos, J., Fabre, J.-M., Ramos, J., Pecheur, E.-I., Larrey, D., Maurel, P., Daujat-Chavanieu, M. Tags: Pancreas and biliary tract Hepatology Source Type: research