Blueprint to reduce wasteful blood transfusions
(Johns Hopkins Medicine) By analyzing data from randomized clinical trials comparing blood transfusion approaches, Johns Hopkins experts, along with colleagues at Cleveland Clinic and NYU Langone Medical Center, endorse recommendations for blood transfusions that reduce blood use to improve patient safety and outcomes. Publishing this week in JAMA Internal Medicine, the report also provides a how-to guide for launching a patient blood management program.
Conclusion: Patient positioning in PCNL does not seem to impact the rates of success or severe complications. However, COMPSUP is associated with a shorter surgical time than the other positions.
ConclusionNaphthalene ingestion can lead to severe intravascular hemolysis as well as methemoglobinemia. The resultant pigment nephropathy may also lead to acute kidney injury.
AbstractEarly detection of myocardial dysfunction is essential for the management of patients with thalassemia. Four-dimensional echocardiography imaging technique may be useful for detecting subclinical cardiovascular disease. To evaluate the 4-dimensional echocardiographic strain in children with beta thalassemia major with no cardiac manifestation and correlate it with other echocardiographic parameters. This is a prospective cross-sectional cohort Study included 200 children, 1 –18 years-old. They were divided into: One hundred children with p-Thalassemia major with no clinical cardiac manifestations and 100...
Authors: Levine NL, Zhang Y, Hoang BH, Yang R, Jurkowski ZH, Roth ME, Gill JB, Lo Y, Eisenberg RE, Bekarev M, Gorlick R, Geller DS Abstract INTRODUCTION: The LigaSure system has been successfully used in thoracic and abdominal surgery. However, to date, its use in the resection of sarcomas has not been systematically studied. We aimed to determine whether the use of the LigaSure system reduces blood loss and blood transfusion volumes in sarcoma surgery. METHODS: One hundred forty-two consecutive patients who underwent sarcoma surgeries between July 2010 and October 2016 were included. Conventional electrocauter...
Conditions: Mitral Valve Replacement; Transfusion Reaction; Blood Transfusion Complication Intervention: Procedure: Mitral valve replacement Sponsors: The Third Xiangya Hospital of Central South University; Second Xiangya Hospital of Central South University; Chinese Academy of Medical Sciences, Fuwai Hospital; The Affiliated Hospital Of Southwest Medical University; Qilu Hospital of Shandong University; Zhejiang Provincial People’s Hospital; Beijing Aerospace&n...
CONCLUSION: Internal iliac artery balloon tamponade decreases blood transfusion requirements among women requiring emergency Caesarean hysterectomy for placenta accreta. Balloon insertion in the operating room may be an important factor in ensuring efficacy of this procedure. Further studies are required to clarify the potential benefits of balloon tamponade in the elective setting. PMID: 30885297 [PubMed - in process]
Conclusion: The findings suggest that the use of sterile wound draping in thoracic surgery procedures reduces surgical site infections and hospitalization costs. PMID: 30886857 [PubMed - in process]
Worldwide, 5.1 million people die every year as a result of traumatic injuries, of which 1 million are in Europe . These traumatic injuries often result in death by major haemorrhage that could have been prevented in an estimated 29% of the civilian and 24% of the military casualties [2,3]. The introduction of prehospital blood-component transfusion (PHBT) with packed red blood cells (pRBCs), fresh frozen plasma (FFP), freeze dried plasma (FDP), or platelets in addition to the individual use of crystalloids – has improved remote damage control and made haemostatic volume replacement possible early after trauma.
β-thalassemia is a hereditary disorder with limited approved treatment options; patients experience anemia and its complications, including iron overload. The study aim was to determine whether luspatercept could improve anemia and disease complications in patients with β-thalassemia. This open-label, nonrandomized, uncontrolled study consisted of a 24-week dose-finding and expansion stage (initial stage) and a 5-year extension stage, currently ongoing. Sixty-four patients were enrolled; 33 were non–transfusion dependent (mean hemoglobin,