Blueprint to reduce wasteful blood transfusions
(Johns Hopkins Medicine) By analyzing data from randomized clinical trials comparing blood transfusion approaches, Johns Hopkins experts, along with colleagues at Cleveland Clinic and NYU Langone Medical Center, endorse recommendations for blood transfusions that reduce blood use to improve patient safety and outcomes. Publishing this week in JAMA Internal Medicine, the report also provides a how-to guide for launching a patient blood management program.
ConclusionsIn patients with significant bleeding following cardiac surgery, PCC administration seems to be more effective than FFP in reducing perioperative blood transfusions. No additional risks of thromboembolic events or other adverse reactions were observed. Randomized controlled trials are needed to definitively establish the safety of PCC in cardiac surgery.
Publication date: Available online 17 November 2018Source: MethodsXAuthor(s): Eva Morbidelli, Julie Rambaldi, Laura Ricci Bitti, Anna Zaghini, Andrea BarbarossaAbstractIvermectin is an endectocide belonging to the macrocyclic lactone class, commonly used in dogs as a heartworm preventative and for the treatment of several external and internal parasite infections. Among the analytical methods for ivermectin determination in plasma available in literature, many require a laborious clean-up step on SPE cartridge, and use fluorescence detection instead of the more reliable mass spectrometry. In the context of a project aimed ...
Conclusions: Despite massive blood transfusion, including very old blood, the duration of red cell storage did not influence outcome in burn patients. Provision of the oldest blood first by Blood Banks is rational, even for massive transfusion.
AbstractGeographical distribution of ABO and RHD antigens is important for blood transfusion services and population genetics studies. There are few data on this topic in Burkina Faso, a multi ‐ethnic country. Our study aims at reporting phenotypic and allelic frequencies of ABO and RHD blood groups among voluntary blood donors from various ethnical regions of Burkina Faso. We conducted a cross‐sectional study including 81,486 blood donors. ABO allelic frequencies were determined usin g the Bernstein method. Differences in phenotypic distribution of blood groups were assessed using the chi‐square test; ap valueB+>...
ConclusionSepsis at referral, liver cirrhosis, and operative bleeding were significantly associated with both early and late morbidities after definitive management of laparoscopic cholecystectomy related major bile duct injuries, so it is crucial to avoid these catastrophes when doing those major procedures.
ConclusionIncreasing quantities of older packed RBCs are associated with increased likelihood of 24-hour mortality in trauma patients receiving massive packed RBC transfusion (≥10 units), but not in those who receive fewer than 10 units.
Rational and appropriate use of blood and blood products is important in a resource limited setting like South Africa. Proper education is required in decision-making and management with regard to blood transfusion. Status of the current knowledge of blood transfusion practice is also necessary in order to identify target areas of teaching and patient management.
In this study ABO genotyping was performed on a series of blood donors and patients to determine their d efinite blood groups. We examined 100 samples with ABO discrepancies from blood donors and patients referred to Tehran Blood Transfusion Center between October 2015 and August 2016. ABO genotyping was performed on all samples with allele specific PCR for differentiation of A, B and O alleles. Exon 6 and 7 of ABO gene were sequenced to confirm the results. The genotyping of donor/patients samples with discrepant results of ABO blood typing consisted of 61 cases of A2 and A2B, 3 cases ofB302 and 4 cases of Aw06. Genotypin...