Pathogenesis, genetics and diagnosis of endometriosis.

[Pathogenesis, genetics and diagnosis of endometriosis]. Presse Med. 2017 Nov 14;: Authors: Daraï E, Ploteau S, Ballester M, Bendifallah S Abstract Endometriosis is a multifactorial pathology. Trans-tubal reflux theory remains valid. Genetic and epigenetic factors associated with immunological perturbations are involved. The role of endocrine disruptors is discussed although epidemiological studies are contradictory. Therapeutics are primarily based on hormonal treatments but better understanding of pathophysiology should allow targeted non-hormonal therapy. The clinical examination is sometimes negative, which should not eliminate the diagnosis and imposes complementary examinations as best as possible by referents. PMID: 29150232 [PubMed - as supplied by publisher]
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research

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CONCLUSIONS: Clinical data about most of the non-hormonal agents are not sufficient to support them as options for replacement therapy for endometriosis. In spite of this, a few drugs like pentoxifylline showed strong potential for real clinical application. PMID: 31809322 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
CONCLUSIONS: TR-HIFU therapy for posterior DIE is feasible. It could be an interesting minimally invasive alternative to surgery for the treatment of rectosigmoid endometriosis if its efficacy and safety is confirmed. This article is protected by copyright. All rights reserved. PMID: 31788875 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
Abstract Vaginal endometrial stromal sarcoma (VESS) is a rare disease. To the best of our knowledge, there have only been a few reported cases in the literature. Therefore, we conducted a literature review to obtain specific knowledge of this disease. Thirteen cases of VESS were found by searching the Medline and EMBASE databases in the English language. The mechanism of VESS may be associated with endometriosis, and its diagnosis largely depends on pathological examination because it has no typical symptoms. Treatment of VESS incorporates surgery, chemotherapy, radiotherapy, and hormonal therapy. Some novel drugs...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Eur J Obstet Gynecol Reprod Biol X Source Type: research
AbstractBackgroundBladder endometriosis (BE) is the most common external site of deep-infiltrating endometriosis (DIE) affecting the urinary tract. Frequently associated with other DIE lesions, it can be strongly related to a ventral spread of adenomyosis. Possible symptoms are urinary frequency, tenesmus and hematuria, and they are frequently related to DIE of the posterior and lateral compartment. Hormonal therapy can be used in non-symptomatic patients; conversely, in other cases surgical treatment is the management of choice.MethodsRetrospective cohort study of a series of consecutive patients treated between September...
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
While typical treatment for endometriosis includes surgery, hormone therapy, and pain medications, some people also use essential oils. Learn whether they are effective here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Endometriosis Source Type: news
Publication date: Available online 10 August 2019Source: The Annals of Thoracic SurgeryAuthor(s): John M. Fallon, Manu S. SanchetiAbstractTwo young female patients presented with clinical findings of catamenial pneumothorax (CP) and thoracic endometriosis syndrome (TES). Despite attempts at conservative management, thoracoscopic pleurodesis, and hormonal therapy, both women experienced recurrent pneumothoraces coincident with menses. Each patient subsequently underwent robotic assisted mechanical pleurectomy and diaphragm reconstruction with durable results.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Abstract Two young female patients presented with clinical findings of catamenial pneumothorax (CP) and thoracic endometriosis syndrome (TES). Despite attempts at conservative management, thoracoscopic pleurodesis, and hormonal therapy, both women experienced recurrent pneumothoraces coincident with menses. Each patient subsequently underwent robotic assisted mechanical pleurectomy and diaphragm reconstruction with durable results. PMID: 31408641 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
This study suggests that certain SNPs of NER genes (ERCC1, ERCC2, and ERCC6) predispose women to the development of endometriosis. PMID: 31373346 [PubMed - as supplied by publisher]
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
AbstractThoracic endometriosis-related non-catamenial pneumothorax is a rare entity whose pathogenesis is still less unclear than catamenial pneumothorax one. Hormonal therapy and/or talc pleurodesis are not sufficient for successful management. Surgical videothoracoscopic resection has a central role in the treatment. We displace a case of thoracic endometriosis-related non-catamenial pneumothorax presenting with recurrent right pneumothorax, surgically treated three times and misdiagnosed at first two interventions. At third operation, unusual histological findings on diaphragmatic and pulmonary specimens were disclosed....
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 28 May 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Gisella Gargiulo-Monachelli, Maria Meyer, Agustina Lara, Laura Garay, Analia Lima, Paulina Roig, Alejandro F. De Nicola, Maria Claudia Gonzalez DeniselleAbstractThe Wobbler mouse has been proposed as an experimental model of the sporadic form of amyotrophic lateral sclerosis (ALS). The administration of natural progesterone (PROG) to Wobbler mice attenuates neuropathology, inhibits oxidative stress, enhances the expression of genes involved in motoneuron function, increases survival and restores axonal ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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