Biological activities of the red algae Galaxaura rugosa and Liagora hawaiiana Butters

Publication date: Available online 13 November 2017 Source:Saudi Pharmaceutical Journal Author(s): Nouf M. Al-Enazi, Amani S. Awaad, Saleh I. Alqasoumi, Metab F. Alwethairi The biological activities; antimicrobial, antioxidant and anticancer, of the red algae Galaxaura rugosa and Liagora hawaiiana were determined. The total ethanol, lipoidal matters, chloroform, n-butanol, aqueous extracts and powder of both algae showed and bacterial and antifungal activities. However, the chloroform extract of Galaxaura rugosa showed antibacterial activity against Klebsiella pneumoniae (24 mm, 0.15 mg/ml) higher than gentamycin (23 mm, 0.49 mg/ml). Moreover, the total ethanol, lipoidal matter and chloroform extracts showed antifungal activity (21, 22 and 25 mm, 1.25, 0.312 and 0.156 mg/ml) similar to the antibiotic Ketoconazole activity (23, 24 and 27 mm, 1.25, 0.312 and 0.156 mg/ml) against Aspergillus fumigatus, A. niger and Candida trobicalis, respectively. A good antioxidant activity (80.96%, IC50= 27.8 µg/ml) was provided by Galaxaura rugosa. The anticancer activity results revealed that the lipoidal matters of Galaxaura rugosa and Liagora hawaiiana possessed antitumor activity (IC50 = 15±1.7 and 21.2±1.6, respectively) against lung carcinoma (A-549) better than vinblastine sulfate (IC50 = 24.6±0.7). Although, the lipoidal matters of Galaxaura rugosa and Liagora hawaiiana antitumor activity against cervical carcinoma (HeLa) and intestinal carcinoma (CACO-2) (IC50 = 10.2±0.6 ...
Source: Saudi Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research