New compounds with anti-inflammatory potential from Disporum cantoniense

Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Zhifeng Li, Huiling Zhao, Hui Ouyang, Qi Wang, Jie Chen, Yulin Feng, Shilin Yang Phytochemical investigation of Disporum cantoniense has resulted in the isolation of two new compounds, namely (3S,4S,5S)-5-C-(4-hydroxy-3-methoxybenzyl)-γ-lactone-2-deoxy-pentonic acid(1) and (3R,4S,5R)-5-C-(4-hydroxy-3-methoxybenzyl) -γ-lactone-2-deoxy-pentonic acid(2). Their structures were elucidated by various spectroscopic techniques. The absolute configurations of compounds were determined by ECD calculations analysis. Compound 1 showed significant inhibition of nitric oxide (NO) release in LPS-induced RAW264.7 macrophages with the IC50 value of 6.43±0.68μM, comparable to that of positive control amino guanidine (9.14±0.62μM). Herein we report the isolation, structure elucidation, as well as the evaluation of the anti-inflammatory activities of these two compounds. Graphical abstract

Source: Phytochemistry Letters - November 19, 2017 Category: Chemistry Source Type: research