Aethusifolins A –D: Four new components from a traditional Mongolian medicinal herb Clematis aethusifolia Turcz

Publication date: December 2017 Source:Phytochemistry Letters, Volume 22 Author(s): Yanxi Chang, Ping Zhang, Jirimubatu Jurhiin, Xuan Zhang, Wuyahan Borgihiin, Hongmei Zhao, Sangho Koo, Wolf-Dieter Rausch, Agula B., Baoquan Bao Four new components named aethusifolins A–D (1–4), together with ten known (5–14) were isolated from the dried aerial parts of a traditional Mongolian medicinal herb Clematis aethusifolia Turcz. The planar structures were established based on extensive spectroscopic analysis (HRMS, 1D and 2D NMR), and the absolute configurations were determined by modified Mosher’s method, hydrolysis method. The cytotoxicities of isolated compounds against a panel of five human solid tumor cell lines were assayed. Compounds 5, 8, and 13 showed moderate cytotoxicity against A-375 with IC50 values of 15–18μM, while compound 8 also showed cytotoxicity against SH-SY5Y with IC50 values of 20μM. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research