Cardioprotective Effects Of Serca2a Overexpression Against Ischemia-Reperfusion-Induced Injuries In Rats.

CONCLUSION: Our findings demonstrated that the overexpression of Serca2a plays an important role in myocardial protection from I/R injury and postischemic functional recovery, which may be via anti-necrotic, anti-apoptotic and pro-autophagy signal pathways. Our research provides solid basic data and new perspective for clinical treatment in heart failure patients with long-term over-expression of Serca2a. PMID: 29141547 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29141547?dopt=Abstract

Source: Current Gene Therapy - November 10, 2017 Category: Genetics & Stem Cells Authors: Jian Y, Tian LL, Wang LH, Zhao XD, Chen JW, Murao K, Zhu W, Dong L, Wang GQ, Sun WP, Zhang GX Tags: Curr Gene Ther Source Type: research