Treatment Strategy for Standard-Dose Proton Pump Inhibitor-Resistant Reflux Esophagitis.

Treatment Strategy for Standard-Dose Proton Pump Inhibitor-Resistant Reflux Esophagitis. J Nippon Med Sch. 2017;84(5):209-214 Authors: Iwakiri K Abstract Reflux esophagitis is characterized by excessive esophageal acid exposure. To treat reflux esophagitis, it is necessary to reduce excessive esophageal acid exposure to within the normal range. The first-line drug for the treatment of reflux esophagitis is a standard-dose proton-pump inhibitor (PPI), which is also recommended by the Evidence-based Clinical Practice Guidelines 2015 for gastroesophageal disease of the Japanese Society of Gastroenterology. It has been reported that the response to a standard dose of PPI in patients with mild reflux esophagitis is 90-100%, and that in patients with severe reflux esophagitis is 80-85%. However, PPI-resistant reflux esophagitis has been increasing. When the standard dose of PPI is not effective, modification of the lifestyle with PPI therapy, switching to another PPI, or a change in the administration method (before meals), as well as double-dose PPI (in divided doses), may be effective. In addition, vonoprazan (potassium-competitive acid blocker), which has rapid and potent acid-suppressive effects, became available in February 2015 in Japan. In the clinical trial data, vonoprazan is very effective for reflux esophagitis. However, clinical data on vonoprazan are still insufficient. The establishment of a new treatment for reflux esophagitis taking advantage o...
Source: Journal of Nippon Medical School - Category: Universities & Medical Training Authors: Tags: J Nippon Med Sch Source Type: research

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Publication date: Available online 13 February 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Beatrix Sik, Erika Lakatos Hanczné, Viktória Kapcsándi, Zsolt AjtonyAbstractThe goal of this study was to improve the extraction efficiency of rosmarinic acid (RA) from Lamiaceae herbs (lemon balm, peppermint, oregano, rosemary, sage, and thyme) using various extraction techniques (maceration with stirring, MACS; heat reflux, HRE; and microwave-assisted extraction, MAE) and extraction conditions (solvent acidity, solvent type, extraction time and temperature). The RA content was measur...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
In this study, two oppositely charged CDs were synthesized and compared for their surface charge dependent interaction with different cell lines. Positively charged CDs were synthesized by using bovine serum albumin (BSA) and negatively charged CDs were synthesized using citric acid (CA) by acidic hydrolysis and reflux methods, respectively. Using both CDs, a concentration dependent cytotoxicity was carried out on 3T3 fibroblast, MDA-MB-231 breast cancer and RAW 264.7 macrophage cell lines, while cellular uptake and inflammatory studies were conducted with RAW 264.7 macrophages cell line. Results showed that both BSA and C...
Source: Colloids and Interface Science Communications - Category: Nanotechnology Source Type: research
In this study, we evaluated the effects of debris – generated on multiwalled carbon nanotubes (MWCNT) subjected to acid oxidation – on the capacities, kinetics and adsorption mechanism. For this, three different MWCNTs were employed: a pristine unmodified MWCNT; an oxidized MWCNT (obtained by common procedure and without the removal of debris); and an oxidized MWCNT without debris (obtained after reflux in alkaline medium). In addition, methylene blue (MB) has been used as model adsorbate in these experiments. As a second goal, the effects of debris on MB faradic electron transfer at the MWCNT interface were al...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
The landscape of gastroesophageal reflux disease (GERD) management is changing, in a good way. Several key forces have converged (Box  1), propelling us to see GERD with a new perspective. One of these forces is the expanding role of the interventional gastrointestinal endoscopist in foregut diseases, including GERD, Barrett’s and early esophageal cancer, achalasia, Zenker diverticulum, early gastric cancer, gastric outlet obst ruction, and obesity. Accordingly, when tapped by Dr Lightdale to be the editor of this issue devoted to GERD management, I had the privilege of assembling some of the top GERD authoritie...
Source: Gastrointestinal Endoscopy Clinics of North America - Category: Gastroenterology Authors: Tags: Preface Source Type: research
ConclusionsComparative trials remain necessary between N-Sleeve and standard bariatric procedures to refine the specific indications of each of them and determine the eventual role of the N-Sleeve.
Source: Obesity Surgery - Category: Surgery Source Type: research
ConclusionsSpecialist-diagnosed CC was associated with considerable disease burden, particularly among those with both respiratory disease and GERD. Additionally, CC burden was more pronounced than in matched non-cough patients.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Condition:   Gastro Esophageal Reflux Intervention:   Diagnostic Test: wireless pH capsule recording Sponsor:   King's College Hospital NHS Trust Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, omeprazole nephrotoxicity may be related to induction of oxidative stress and renal tubular cell death.
Source: Redox Biology - Category: Biology Source Type: research
Magnetic sphincter augmentation is an effective and safe surgical method for the treatment of gastroesophageal reflux disease (GERD). The device has been compared with twice-daily proton pump inhibitor therapy and laparoscopic fundoplication (in randomized trials and prospective cohort studies, respectively). Magnetic sphincter augmentation was superior to medical therapy and equivalent to surgery for the relief of GERD symptoms. Recent research focuses on implanting the device into more complex patients, such as those with larger hiatal hernias or those with Barrett ’s esophagus. Additional novel research topics inc...
Source: Gastrointestinal Endoscopy Clinics of North America - Category: Gastroenterology Authors: Source Type: research
Minimally invasive endoscopic antireflux therapies are critical for bridging the gap between medical and surgical treatments for gastroesophageal reflux disease (GERD). Although multiple endoscopic devices have been developed, perhaps some of the most exciting options that are currently evolving are the full-thickness suturing techniques using widely available and low-cost platforms. Full-thickness endoscopic suturing can allow for a highly durable recreation of the anatomic and functional components of a lower esophageal sphincter, which are deficient in patients with GERD. Proper patient selection, endoscopic hiatal hern...
Source: Gastrointestinal Endoscopy Clinics of North America - Category: Gastroenterology Authors: Source Type: research
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