Discovery of a promising medication for amyotrophic lateral sclerosis (ALS)
Researchers from the University of Montréal Hospital Research Centre (CRCHUM) and the Cumming School of Medicine (CSM) at the University of Calgary have discovered a medication that could make it possible to treat individuals with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. An article published today in JCI Insight concludes that pimozide was found to be safe and over the short term, preliminary data shows that it could stabilize the progression of ALS.
Condition: Amyotrophic Lateral Sclerosis Intervention: Drug: Riluzole Oral Soluble film (ROSF) 50 mg Sponsors: Aquestive Therapeutics; inVentiv Health Clinical; Covance Enrolling by invitation
Brain and Behavior, EarlyView.
In this study, we aimed to compare the immunomodulatory properties of MSCs isolated from the bone marrow of patients suffering from ALS and healthy donors. Moreover, the influence of proinflammatory cytokines on the immunoregulatory functions of MSCs was also evaluated. We found that MSCs from ALS patients and healthy donors comparably affected mitogen-stimulated peripheral blood mononuclear cells and reduced the percentage of T helper (Th)1, Th17 and CD8+CD25+ lymphocytes. These MSCs also equally increased the percentage of Th2 and CD4+FOXP3+ T lymphocytes. On the other hand, MSCs from ALS patients decreased more strongly...
Journal of Cellular Physiology, EarlyView.
AbstractNeuromuscular disorder is a muscular and nervous disorder resulting in muscular weakness and progressively damages nervous control, such as amyotrophic lateral sclerosis (ALS) and myopathy (MYO). Its diagnosis can be possible by classification of ALS, MYO, and normal electromyogram (EMG) signals. In this paper, an effective method based on variational mode decomposition (VMD) is proposed for identification of neuromuscular disorder of EMG signals. VMD is an adaptive signal decomposition which decomposes EMG signals nonrecursively into band-limited functions or modes. These modes are used for extraction of spectral ...
Publication date: October 2018Source: The Lancet Neurology, Volume 17, Issue 10Author(s): Miguel Leal Rato, Gonçalo S Duarte, Tiago Mestre, Mamede de Carvalho, Joaquim J Ferreira
Publication date: Available online 18 September 2018Source: Pharmacological ResearchAuthor(s): Yajuan Xiao, Chehade Karam, Jianxun Yi, Lin Zhang, Xuejun Li, Dosuk Yoon, Huan Wang, Kamal Dhakal, Paul Ramlow, Tian Yu, Zhaohui Mo, Jianjie Ma, Jingsong ZhouAbstractIn amyotrophic lateral sclerosis (ALS), mitochondrial dysfunction and oxidative stress form a vicious cycle that promotes neurodegeneration and muscle wasting. To quantify the disease-stage-dependent changes of mitochondrial function and their relationship to the generation of reactive oxygen species (ROS), we generated double transgenic mice (G93 A/cpYFP) tha...
International Journal of Clinical Practice, EarlyView.
Conclusions Considering phonetic complexity for dysarthria tests could result in more sensitive assessments for detecting and monitoring dysarthria progression.
Muscle&Nerve,Volume 0, Issue ja, -Not available-.