MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB ‐NFIB fusion gene

In conclusion, we demonstrate that MYBL1 rearrangements and MYB amplification likely constitute alternative genetic drivers of breast AdCCs, functioning through MYBL1 or MYB overexpression. These observations emphasize that breast AdCCs likely constitute a convergent phenotype, whereby activation of MYB/MYBL1 and their downstream targets can be driven by the MYB‐NFIB fusion gene, MYBL1 rearrangements, MYB amplification or other yet to be identified mechanisms.

Source: The Journal of Pathology - November 17, 2017 Category: Pathology Authors: Jisun Kim, Felipe C. Geyer, Luciano G Martelotto, Charlotte K Y Ng, Raymond S Lim, Pier Selenica, Anqi Li, Fresia Pareja, Nicola Fusco, Marcia Edelweiss, Rahul Kumar, Rodrigo Gularte ‐Merida, Andre N Forbes, Ekta Khurana, Odette Mariani, Sunil Badve, An Tags: Brief Definitive Report Source Type: research