TGF- β1 and CXCL12 modulate proliferation and chemotherapy sensitivity of acute myeloid leukemia cells co-cultured with multipotent mesenchymal stromal cells.

CONCLUSION: These findings suggest a strong supporting affinity between MSCs and AML cells within the leukemic niche, where TGF-β1 and CXCL12 pathways play an important role. PMID: 29140182 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29140182?dopt=Abstract

Source: Hematology - November 17, 2017 Category: Hematology Tags: Hematology Source Type: research