Vitamin B12 deficiency in inflammatory bowel disease: a prospective observational pilot study

This study aims to determine the proportion of IBD patients with Cbl concentrations below reference range and their predisposing clinical and genetic characteristics. We then compared this to the proportion with true deficiency. Patients and methods In a prospective observational pilot study of adult IBD outpatients, Cbl concentrations, MMA levels, and fucosyltransferase 2 mutations were measured at clinic visits. Results A total of 66 Crohn’s disease (CD) and 30 ulcerative colitis (UC) patients were recruited. Mean Cbl concentrations (pmol/l) in CD (253.7) were not significantly lower than UC (320.5, P=0.24). Serum Cbl below reference range (
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Inflammatory Bowel Diseases Source Type: research