Vitamin B12 deficiency in inflammatory bowel disease: a prospective observational pilot study

This study aims to determine the proportion of IBD patients with Cbl concentrations below reference range and their predisposing clinical and genetic characteristics. We then compared this to the proportion with true deficiency. Patients and methods In a prospective observational pilot study of adult IBD outpatients, Cbl concentrations, MMA levels, and fucosyltransferase 2 mutations were measured at clinic visits. Results A total of 66 Crohn’s disease (CD) and 30 ulcerative colitis (UC) patients were recruited. Mean Cbl concentrations (pmol/l) in CD (253.7) were not significantly lower than UC (320.5, P=0.24). Serum Cbl below reference range (
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Inflammatory Bowel Diseases Source Type: research

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Publication date: Available online 24 May 2020Source: PharmaNutritionAuthor(s): Seyed Mostafa Arabi, Leila Sadat Bahrami, Golnaz Ranjbar, Hamed Tabesh, Abdolreza Norouzy
Source: PharmaNutrition - Category: Nutrition Source Type: research
Despite the power of vitamin D to restore or increase many aspects of health, so many people–including doctors–continue to be unaware of several important aspects of this crucial nutrient. Being aware and managing these simple details can put you on course to take full advantage of vitamin D and its impressive role in health, including maximal protection against viral illnesses. The post 10 Things You Probably Didn’t Know About Vitamin D: Essential Info During a Pandemic appeared first on Dr. William Davis.
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open undoctored vitamin D wheat belly Source Type: blogs
Authors: Chan VS Abstract Multiple sclerosis (MS) is an aggravating autoimmune disease that cripples young patients slowly with physical, sensory and cognitive deficits. The break of self-tolerance to neuronal antigens is the key to the pathogenesis of MS, with autoreactive T cells causing demyelination that subsequently leads to inflammation-mediated neurodegenerative events in the central nervous system. The exact etiology of MS remains elusive; however, the interplay of genetic and environmental factors contributes to disease development and progression. Given that genetic variation only accounts for a fraction ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conditions:   Vitamin D Status;   Osteoporosis;   Sarcopenia Intervention:   Sponsors:   University of Ulster;   Western Health and Social Care Trust Suspended
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Restorative proctocolectomy (RP) is a common surgical procedure utilized in the management of inflammatory bowel disease (IBD), primarily ulcerative colitis (UC). This procedure involves removal of the colon, and the formation of a pouch from the distal portion of the ileum, the primary site for absorption of vitamin B12. Vitamin B12 deficiency has been linked to fatigue, depression, memory loss, weakness, neuropathy, and altered bowel habits. In RP, surgical manipulation of the ileum, an altered microbiota, and pouchitis may potentially impair vitamin B12 status.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Disease Complications Source Type: research
ConclusionAlthough the overall prevalence of RLS in IBD did not differ to the general population, clinically relevant RLS was more frequent in IBD patients and, therefore, it is important for clinicians to be aware of RLS symptoms. Though for definite diagnosis and proper treatment of RLS, a neurologist must be consulted. Additionally, iron supplementation of IBD patients with ID can improve RLS symptoms.Trial registrationClinicalTrials.gov No.NCT03457571
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
A recently published clinical guideline on vitamin and mineral supplements reinforces every other evidence-based guideline, research review, and consensus statement on this topic. The bottom line is that there is absolutely no substitute for a well-balanced diet, which is the ideal source of the vitamins and minerals we need. The brief article, co-authored by nutrition guru Dr. JoAnn Manson, cites multiple large clinical trials studying multiple nutritional supplements’ effects on multiple end points. The gist of it is, our bodies prefer naturally occurring sources of vitamins and minerals. We absorb these better. An...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Drugs and Supplements Health Healthy Eating Prevention Vitamins and supplements Source Type: blogs
AbstractIt has been reported that abnormal elevation of homocysteine is quite prevalent in ulcerative colitis (UC) patients. We attempted to explore the relationship of UC with transcobalamin II (TCN2) gene polymorphisms and serum homocysteine, vitamin B12, and folate levels in Chinese patients.TCN2 (rs1801198, rs9606756) genotypes were detected by the improved multiple ligase detection reaction (iMLDR) technique in 527 UC patients and 574 controls. Moreover, 128 UC patients and 138 controls were randomly selected for the measurement of homocysteine, vitamin B12, and folate levels by enzymatic cycling assay or chemilumines...
Source: Immunogenetics - Category: Genetics & Stem Cells Source Type: research
Conclusion Micronutrient deficiencies were frequent in our study cohort and did not correlate with macronutrient status. Measurement of macronutrients and micronutrients should become a routine assessment in IBD patients to improve patient care and to avoid negative repercussions on disease activity.
Source: Australasian Medical Journal - AMJ - Category: Journals (General) Source Type: research
Background: Crohn's disease (CD) is a risk factor for vitamin B12 deficiency due to frequent involvement of the terminal ileum. Conventional screening for B12 deficiency with serum B12 is relatively insensitive and measures total B12 concentration, of which a minority is present in a biologically active form. Holotranscobalamin (holoTC) combined with methylmalonic acid (MMA) is believed to be more accurate in identifying impaired B12 status. We evaluated the prevalence and risk factors for B12 deficiency using holoTC supported by MMA among patients with CD. Methods: We performed a single-center service evaluation of 381 pa...
Source: Inflammatory Bowel Diseases - Category: Gastroenterology Tags: Original Clinical Articles Source Type: research
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