Efficacy and Safety of Citalopram Compared With Atypical Antipsychotics on Agitation in Nursing Home Residents With Alzheimer Dementia

We are delighted to know that our article has captured the attention of readers. Regarding the findings of our previous study, Professor Naharci points out that unrecognized delirium could have had a relevant confounding effect and that the differential role of specific antidementia drugs should have been analyzed in detail. Delirium is a common geriatric syndrome with the highest incidence in acutely ill hospitalized older patients.1 Professor Naharci cited a retrospective study by Dosa et  al2 reporting a very high occurrence of either full-spectrum or subsyndromal delirium among long-stay residents.
Source: Journal of the American Medical Directors Association - Category: Health Management Authors: Tags: Letter to the Editor Source Type: research

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Conditions:   Mild Cognitive Impairment;   Dementia;   Intermittent Claudication Intervention:   Behavioral: Leg ischemia Sponsors:   Aristotle University Of Thessaloniki;   Greek Alzheimer's Association and Related Disorders Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: November 2019Source: Alzheimer's &Dementia, Volume 15, Issue 11Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: November 2019Source: Alzheimer's &Dementia, Volume 15, Issue 11Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: November 2019Source: Alzheimer's &Dementia, Volume 15, Issue 11Author(s): Stacie Weninger, Bjorn Sperling, Lisa J. Bain, Maria C. Carillo
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: November 2019Source: Alzheimer's &Dementia, Volume 15, Issue 11Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
DiscussionThe Cognigram was well liked in waiting rooms of primary care settings. Assistance from a trained adult and clinic endorsement were keys to success. How the Cognigram performs in a geographically compact, population-dense global setting, such as Brooklyn with high vascular disease risk and a plethora of health disparities, is being tested.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: November 2019Source: Alzheimer's &Dementia, Volume 15, Issue 11Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Publication date: November 2019Source: Alzheimer's &Dementia, Volume 15, Issue 11Author(s):
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121 and J147, were used to identify a unique molecular pathway that is shared between the aging brain and AD. CMS121 and J147 reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. Both compounds preserved mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. C...
Source: eLife - Category: Biomedical Science Tags: Neuroscience Source Type: research
Conclusion: FDG-PET-based visual and cortex ID classification has a good accuracy in predicting progression to dementia including AD in the prodromal aMCI phase. Absence of typical metabolic patterns on FDG-PET can play an important exclusionary role for progression to dementia. Vascular cognitive impairment with cerebral atrophy needs further studies to confirm and uncover potential mechanisms.
Source: Neurology India - Category: Neurology Authors: Source Type: research
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