FDA Turns to Emerging Tech for Opioid Crisis

It will take more than medication alone to win the battle against opioid addiction, and now U.S. clinicians finally have a device-based therapy to help reduce the symptoms of opioid withdrawal. FDA granted a new indication to Innovative Health Solutions for its NSS-2 Bridge nerve stimulator. The new indication was reviewed under FDA's de novo pathway. “There are three approved drugs for helping treat opioid addiction. While we continue to pursue better medicines for the treatment of opioid use disorder, we also need to look to devices that can assist in this therapy,” said FDA Commissioner Scott Gottlieb, MD. Gottlieb said FDA supports the development of both drug and device-based treatments that can be used to address opioid dependence or addiction, as well as new, non-addictive treatments for pain that can serve as alternatives to opioids. The NSS-2 Bridge device is a small electrical nerve stimulator placed behind the patient’s ear. It contains a battery-powered chip that emits electrical pulses to stimulate branches of certain cranial nerves. Such stimulations may provide relief from opioid withdrawal symptoms, the agency noted. The device is placed behind the ear with microneedle arrays that percutaneously implant in and around the ear. Patients can use the device for up to five days during the acute physical withdrawal phase. Opioid withdrawal causes acute physical withdrawal symptoms including sweating, gastrointestinal upset, agitation, insomnia, and...
Source: MDDI - Category: Medical Devices Authors: Tags: Regulatory and Compliance Source Type: news

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Dario Kringel, Mari A. Kaunisto, Catharina Lippmann, Eija Kalso, J örn Lötsch
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, broccoli sprouts, SFN and CA are potential nutraceuticals for abdominal pain therapy.Graphical abstractSulforaphane (SFN) produces abdominal antinociception and a concentration-dependent spasmolytic activity involving the opioid system and calcium channels, respectively.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
In conclusion, the present study provided a better understanding of the molecular fragments requisite for maintaining and/or improving FAAH inhibition activity.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Oh HS, Ha J, Kim HI, Kim TH, Kim WG, Lim DJ, Kim TY, Kim SW, Kim WB, Shong Y, Chung JH, Baek JH Abstract Background: Active surveillance has been introduced as an alternative management option for low-risk papillary thyroid microcarcinoma (PTMC), due to its indolence. Methods: This is a multi-center study of 370 PTMC patients who underwent active surveillance more than 1 year. The changes in volume and maximum diameter between initial and last ultrasonography were evaluated to identify the natural course of PTMC during active surveillance Results: Patients' age at diagnosis was 51±12 years, and 110 patients (30%) were
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Professor Amy Brown, researcher at Swansea University and infant feeding expert, explains most women should be able to breastfeed without worrying about pain or not producing enough milk.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Professor Amy Brown, researcher at Swansea University and infant feeding expert, explains most women should be able to breastfeed without worrying about pain or not producing enough milk.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Taha MM, Mahdy-Abdallah H, Shahy EM, Ibrahim KS, Elserougy S Abstract Cadmium (Cd) is one of the environmental risk factors for bone loss. The present study included 40 sewage workers occupationally exposed to Cd. Forty nonexposed men were included as a control group. Current smokers represented 65% and 47.5% of the exposed and control groups, respectively. The study aimed to investigate the hazard of occupational Cd exposure on bone health. This was achieved through measuring serum and urinary Cd, and calcium (Ca), in addition to serum osteoprotegerin (OPG) and estrogen receptor-α gene. Results show...
Source: International Journal of Occupational and Environmental Health - Category: Environmental Health Tags: Int J Occup Environ Health Source Type: research
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