Increased Hyperalgesia and Proinflammatory Cytokines in the Spinal Cord and Dorsal Root Ganglion After Surgery and/or Fentanyl Administration in Rats.

CONCLUSIONS: The surgical plantar incision with or without perioperative fentanyl induced significant mechanical and thermal hyperalgesia, an increased expression of IL-1β, IL-6, TNF-α in the spinal cord and DRG, and activation of microglia in the spinal cord.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. PMID: 29135586 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29135586?dopt=Abstract

Source: Anesthesia and Analgesia - November 10, 2017 Category: Anesthesiology Authors: Chang L, Ye F, Luo Q, Tao Y, Shu H Tags: Anesth Analg Source Type: research