Reproducibility in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity

Low reproducibility rates are a concern in most, if not all, scientific disciplines. In psychiatric genetics specifically, intermediate brain phenotypes more proximal to putative genetic effects were touted as a strategy leading to increased power and reproducibility. Here we attempt to replicate previously published associations between single nucleotide polymorphisms (SNPs) and threat-related amygdala reactivity, which represents a robust brain phenotype not only implicated in the pathophysiology of multiple disorders, but also as a biomarker of future risk.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Archival Report Source Type: research