Marburg virus disease – Uganda and Kenya

Disease Outbreak News Uganda Kenya Marburg virus disease
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news

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ConclusionThis outbreak of MVD occurred as a family cluster with no additional transmission outside of the four related cases. Rapid case detection, prompt laboratory testing at the Uganda National VHF Reference Laboratory and presence of pre-trained, well-prepared national and district rapid response teams facilitated the containment and control of this outbreak within one month, preventing nationwide and global transmission of the disease.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
ing Bats are known to harbor and transmit many emerging and re-emerging viruses, many of which are extremely pathogenic in humans but do not cause overt pathology in their bat reservoir hosts: henipaviruses (Nipah and Hendra), filoviruses (Ebola and Marburg), and coronaviruses (SARS-CoV and MERS-CoV). Direct transmission cycles are often implicated in these outbreaks, with virus shed in bat feces, urine, and saliva. An additional mode of virus transmission between bats and humans requiring further exploration is the spread of disease via arthropod vectors. Despite the shared ecological niches that bats fill with many h...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Marceline Côté Filoviruses, such as Ebola virus (EBOV) and Marburg virus, are causative agents of unpredictable outbreaks of severe hemorrhagic fevers in humans and non-human primates. For infection, filoviral particles need to be internalized and delivered to intracellular vesicles containing cathepsin proteases and the viral receptor Niemann-Pick C1. Previous studies have shown that EBOV triggers macropinocytosis of the viral particles in a glycoprotein (GP)-dependent manner, but the molecular events required for filovirus internalization remain mostly unknown. Here we report that the diacylglycerol kina...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Uganda is one of the few countries in Africa that has been experiencing outbreaks of viral hemorrhagic fevers such as Ebola, Marburg and Crimean-Congo Hemorrhagic fevers. In 2017 Uganda experienced a Marburg V...
Source: BMC Public Health - Category: Consumer Health News Authors: Tags: Research article Source Type: research
Source: United Kingdom Department of Health (DH). Published: 1/10/2019. This Web page, updated in January 2019, provides information about incidents and outbreaks of Ebola and Marburg, both viral hemorrhagic fevers (VHF). It describes current incidents and outbreaks, including the outbreak of Ebola virus disease in North-Kivu Province, Democratic Republic of Congo (DRC); outbreaks in 2017; the West Africa outbreak 2014 to 2016; linked Ebola outbreaks and cases in other countries (2014 to 2015); and a historic map of outbreaks. (Text)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: International Medicine & Public Health Source Type: news
achedjian The filoviruses Ebolavirus and Marburgvirus are among the deadliest viral pathogens known to infect humans, causing emerging diseases with fatality rates of up to 90% during some outbreaks. The replication cycles of these viruses are comprised of numerous complex molecular processes and interactions with their human host, with one key feature being the means by which nascent virions exit host cells to spread to new cells and ultimately to a new host. This review focuses on our current knowledge of filovirus egress and the viral and host factors and processes that are involved. Within the virus, these factors ...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
The discovery marks the first time the pathogen — a cousin of Ebola — has been found in West Africa, raising the potential for it to cause outbreaks in humans in a new region.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Source: Global Public Health - Category: International Medicine & Public Health Authors: Source Type: research
At the close of the 2014-2016 West Africa Ebola crisis, the Paul G. Allen Foundation identified diagnostic gaps as one of the major deficiencies that had contributed to the outbreak’s spread. “The standard diagnostic tests that exist are very good, but they’re hard to do out in the field in the middle of an outbreak like we saw in West Africa,” said John Connor, a virologist at the Boston University National Emerging Infectious Diseases Laboratory (NEIDL). Instead, samples need to be sent to a facility capable of running the tests, which means it could...
Source: MDDI - Category: Medical Devices Authors: Tags: IVD Source Type: news
Publication date: Available online 11 December 2018Source: Antiviral ResearchAuthor(s): Christopher F. Basler, Nevan J. Krogan, Daisy W. Leung, Gaya K. AmarasingheAbstractFiloviruses, which include Ebola virus and Marburg virus, are negative-sense RNA viruses associated with sporadic outbreaks of severe viral hemorrhagic fever characterized by uncontrolled virus replication. The extreme virulence and emerging nature of these zoonotic pathogens make them a significant threat to human health. Replication of the filovirus genome and production of viral RNAs requires the function of a complex of four viral proteins, the nucleo...
Source: Antiviral Therapy - Category: Virology Source Type: research
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