Metaplastic spindle cell carcinoma of the breast in a patient with neurofibromatosis type 1

We report a unique case of a 67‐year‐old woman with neurofibromatosis type 1, who was also diagnosed with metaplastic spindle cell carcinoma of the left breast. She had many neurofibromatosis lesions on her body, as well as the mass in the left breast. After the breast mass was diagnosed as a malignant mesenchymal tumor by core needle biopsy, the patient underwent left modified radical mastectomy. Subsequently, the pathological analysis of the tumor showed it to be a metaplastic spindle cell carcinoma. The co‐occurrence of neurofibromatosis type 1 and breast cancer, in particular metaplastic spindle cell carcinoma, is very rare.
Source: The Breast Journal - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research

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Dinesh Pradhan, Neeraj Kaur, Ashmita Gami, Kanwaljeet S Hura, Garima Garg, Sambit K MohantyJournal of Cancer Research and Therapeutics 2017 13(3):583-585 Neurofibromatosis type 1 (NF-1) is a neurocutaneous syndrome with autosomal dominant mode of inheritance and has a high propensity to develop benign and malignant nervous system tumors. Although uncommon, case reports describing the association of NF-1 and breast cancer are available in the literature. We illustrate one such case of NF-1, with no family history of the disorder and presenting with multifocal invasive carcinoma of the right breast, in an attempt to describ...
Source: Journal of Cancer Research and Therapeutics - Category: Cancer & Oncology Authors: Source Type: research
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Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research
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Source: Dermatology Online Journal - Category: Dermatology Source Type: research
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