Loss of peri-Wolffian duct stromal Frs2 α expression in mice leads to abnormal ureteric bud induction and vesicoureteral reflux.

ConclusionFrs2α(ST-/-) embryos have aberrant ureteric induction sites, improper ureteral insertion, shortened intravesicular lengths, and VUR. Induction site defects appear secondary to reduced Bmp4 expression, similar to Fgfr2 mutants. PMID: 29135976 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29135976?dopt=Abstract

Source: Pediatric Research - November 15, 2017 Category: Pediatrics Authors: Narla D, Slagle SB, Schaefer CM, Bushnell DS, Puri P, Bates CM Tags: Pediatr Res Source Type: research

More News: Pediatrics | Ureter and Renal Pelvis Cancer