Tadalafil, a long acting phosphodiesterase inhibitor, promotes bone marrow stem cell survival and their homing into ischemic myocardium for cardiac repair

Conclusions: Tadalafil prolonged MSCs survival via up‐regulation of miR‐21 dependent suppression of Fas, and increased MSCs mobilization and their homing into infarcted myocardium resulting in improved cardiac repair and function. Tadalafil prolonged MSCs survival in vitro and in vivo, and increased MSCs mobilization and their homing into infarcted myocardium resulting in improved cardiac repair and function.
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research