Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics.

Endomorphins: Promising Endogenous Opioid Peptides for the Development of Novel Analgesics. Neurosignals. 2017 Nov 13;25(1):98-116 Authors: Gu ZH, Wang B, Kou ZZ, Bai Y, Chen T, Dong YL, Li H, Li YQ Abstract Endomorphin-1 (EM1) and endomorphin-2 (EM2) are two endogenous ligands that belong to the opioid peptide family and have the highest affinity and selectivity for the µ-opioid receptor (MOR). The neuroanatomical distribution, ultrastructural features and neural circuitry of EM-containing neuronal structures have been morphologically demonstrated. In addition, the modulation effects of the EMs in different areas reflect their potential endogenous roles in many major physiological processes, including their remarkable roles in the transmission and modulation of noxious information. The distinguished antinociceptive property of the EMs in acute and chronic pain, including neuropathic pain, cancer pain and inflammatory pain, has been revealed and investigated for therapeutic purposes. However, EMs exert adverse effects in the gastrointestinal, urinary, cardiovascular, and respiratory systems, which impede the development of EMs as new analgesics. Numerous studies have synthesized and investigated EM analogues and demonstrated that these EM derivatives had improved pharmacological properties, supporting their therapeutic perspectives. In the present review, the results of previous studies, particularly morphological and pharmacological studies, were ...
Source: Neuro-Signals - Category: Neurology Authors: Tags: Neurosignals Source Type: research

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Endometriosis is a complex, heterogeneous, chronic inflammatory condition impacting ~176 million women worldwide. It is associated with chronic pelvic pain, infertility, and fatigue, and has a substantial impact on health-related quality of life. Endometriosis is defined by the growth of endometrial-like tissue outside the uterus, typically on the lining of the pelvic cavity and ovaries (known as “lesions”). Macrophages are complex cells at the center of this enigmatic condition; they are critical for the growth, development, vascularization, and innervation of lesions as well as generation of pain symptoms. In...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
There are a few number of comparative studies between duloxetine and pregabalin in the treatment of neuropathic pain from Turkey and as well as we know this is the first study comparing these treatments in lung cancer patients. Our aim is to show the efficacy of duloxetine and pregabalin and compare their efficacy in neuropathic pain of lung cancer patients. AbstractIntroductionNeuropathic pain occurs in 1% of the population and is difficult to manage. This chronic pain causes psychological distress and impacts patient's quality of life, especially in cancer patients. The aim of this study was to show and compare the effic...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Compared with placebo, cannabinoids show no improvement in pain scores in adult cancer patients
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Oncology, Pharmacy, Anesthesiology & amp; Pain, Journal, Source Type: news
Publication date: Available online 17 January 2020Source: Neuroscience LettersAuthor(s): Lauren M. Styczynski, Katie A. Schappacher, Mark L. BacceiAbstractEarly life administration of vincristine (VNC), commonly used to treat pediatric leukemia, evokes peripheral neuropathy and mechanical pain hypersensitivity in rats that lasts into adolescence. However, the degree to which VNC-evoked neuropathic pain persists throughout adulthood has yet to be examined. It also remains unclear if pediatric VNC exposure can ‘prime’ developing nociceptive pathways and thereby exacerbate chronic pain following subsequent trauma ...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
AIM: To understand the potential harmful effects of dose escalation among patients with chronic, non-cancer pain (CNCP) on chronic opioid therapy. DESIGN: Retrospective cohort study. SETTING: United States Veterans Healthcare Administration. PARTIC...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
AbstractPatients with hematologic cancers often develop acute and chronic oral complications from their disease and its treatment. These problems could change patients ’ oral health-related quality of life (OHRQoL) negatively. Quality of life (QoL) has become an increasingly important outcome measure in oncology. This systematic literature review evaluates the impact of hematological malignancies and their treatment on OHRQoL as assessed by the Oral Health Impa ct Profile (OHIP-14) questionnaire. Medline through Pubmed and Web of Science were searched through April 2017. Two randomized controlled trials, one coh...
Source: Odontology - Category: Dentistry Source Type: research
Beyond its effects on the body, medical care can be a balm for the mind. Extensive treatment can feel like a promise that doctors have done everything possible. But that perceived security can come at a high price. As health costs soar, patients are emptying their pockets for care that may not make them healthier, research suggests. Last year, a 5,000-person trial showed that for patients with chronic but stable heart disease, surgical procedures such as stenting and bypass did not reduce the risk of heart attack or death more than lifestyle interventions and medication. Even patients with extensive damage did not, on aver...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Surgery Source Type: news
Publication date: March 2020Source: Biomedicine &Pharmacotherapy, Volume 123Author(s): Qiuyan Guo, Koji Mizuno, Katsuki Okuyama, Na Lin, Yanqiong Zhang, Hideki Hayashi, Norio Takagi, Takashi SatoAbstractWu-tou decoction (WTD), a classic Traditional Chinese medicine formula, has been extensively used in the treatment of neuropathic pain (NP) such as chronic inflammatory pain, trigeminal neuralgia, and cancer-induced pain. Our previous studies have shown that the severity of mechanical allodynia and thermo hypersensitivity in NP rats are reduced by WTD, of which analgesic candidates are paeoniflorin (Pae) and liquiritin ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
a Cruz Diane Liu Eduardo Bruera Palliative care is seeing cancer patients earlier in the disease trajectory with a multitude of chronic issues. Chronic non-malignant pain (CNMP) in cancer patients is under-studied. In this prospective study, we examined the prevalence and management of CNMP in cancer patients seen at our supportive care clinic for consultation. We systematically characterized each pain type with the Brief Pain Inventory (BPI) and documented current treatments. The attending physician made the pain diagnoses according to the International Association for the Study of Pain (IASP) task force classific...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In this study, the authors hypothesized that the endoplasmic reticulum stress triggered by inflammatory mediators contributed to pain development.Methods The authors used a male mouse model of bone cancer pain. The control mice were intrathecally injected with tumor necrosis factor- α (TNF-α) and lipopolysaccharide, the bone cancer pain mice were intrathecally injected with the endoplasmic reticulum stress inhibitors 4-PBA and GSK2606414. The nociceptive behaviors, endoplasmic reticulum stress markers, and inflammatory mediators were assessed.Results Increased expression of the p-RNA-dependent protein kinase-li...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
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