Galectin-3: mediator of microglia responses in injured brain.

Galectin-3: mediator of microglia responses in injured brain.
Drug Discov Today. 2017 Nov 10;:
Authors: Rahimian R, Béland LC, Kriz J
Abstract
Galectin-3 is a pleiotropic protein involved in cell activation, proliferation and migration and plays a pivotal part as an inflammatory mediator in neurodegeneration. Galectin-3 is associated with microglial activation and proliferation after ischemia. Given its putative role as a dynamic fine-tuner of microglia, activation of Galectin-3 provides molecular cues in design of new immunomodulatory strategies for stroke management. This review summarizes recent evidence on the role of Galectin-3 as a mediator of immune responses in damaged brain and mechanisms employed by Galectin-3 to affect microglial function.
PMID: 29133191 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - November 10, 2017 Category: Drugs & Pharmacology Authors: Rahimian R, Béland LC, Kriz J Tags: Drug Discov Today Source Type: research