Scientists Have Made Their First Attempt at Gene Editing Inside a Human Patient
(OAKLAND, Calif.) — Scientists for the first time have tried editing a gene inside the body in a bold attempt to permanently change a person’s DNA to try to cure a disease. The experiment was done Monday in California on 44-year-old Brian Madeux. Through an IV, he received billions of copies of a corrective gene and a genetic tool to cut his DNA in a precise spot. “It’s kind of humbling” to be the first to test this, said Madeux, who has a metabolic disease called Hunter syndrome. “I’m willing to take that risk. Hopefully it will help me and other people.” Signs of whether it’s working may come in a month; tests will show for sure in three months. If it’s successful, it could give a major boost to the fledgling field of gene therapy. Scientists have edited people’s genes before, altering cells in the lab that are then returned to patients. There also are gene therapies that don’t involve editing DNA. But these methods can only be used for a few types of diseases. Some give results that may not last. Some others supply a new gene like a spare part, but can’t control where it inserts in the DNA, possibly causing a new problem like cancer. This time, the gene tinkering is happening in a precise way inside the body. It’s like sending a mini surgeon along to place the new gene in exactly the right location. “We cut your DNA, open it up, insert a gene, stitch it back up. Invisible mending,&rd...
Publication date: Available online 4 April 2020Source: Journal of Geriatric OncologyAuthor(s): Kelly M. Trevino, Amy Stern, Holly G. Prigerson
Publication date: Available online 4 April 2020Source: Journal of Geriatric OncologyAuthor(s): Claire A. Surr, Rachael Kelley, Alys W. Griffiths, Laura Ashley, Fiona Cowdell, Ann Henry, Michelle Collinson, Ellen Mason, Amanda J. Farrin
Publication date: Available online 3 April 2020Source: Autoimmunity ReviewsAuthor(s): Dennis McGonagle, Kassem Sharif, Anthony O'Regan, Charlie Bridgewood
Publication date: Available online 3 April 2020Source: Autoimmunity ReviewsAuthor(s): Felice Rivellese, Edoardo Prediletto
Publication date: Available online 4 April 2020Source: Materials Chemistry and PhysicsAuthor(s): Subhash Sharma, Samar Jana
Abstract OBJECTIVES: To identify and discuss scientific evidence of the effects of ginger use on the management of chemotherapy-induced nausea and vomiting. METHODS: This is an integrative reviewperformed by Ganong's reference. RESULTS: We included 24 studies, highlighting three thematic categories, namely 1) antiemetic action of ginger - nausea (13 articles; of these, nine significant) and emesis (10 studies; of these, six significant); 2) action in the control of nausea (11 articles; of these, six significant) and vomiting (8 articles; of these, three significant) in the acute phase; 3) action in the c...
CONCLUSIONS: different predictors were identified to ECMO complications. The knowledge of these predictors enables the individualized targeting of preventive interventions by multidisciplinary team for modifiable factors, as well as intensification of monitoring for early recognition of non-modifiable factors. PMID: 32236371 [PubMed - in process]
Connection between SOX7 Expression and Breast Cancer Prognosis. Med Sci Monit. 2020 Apr 02;26:e921510 Authors: Qin CX, Yang XQ, Zhan ZY Abstract BACKGROUND SOX7 exerts a repressing effect against tumors and imposes vital influences on malignancies. Our research discussed the importance of SOX7 in breast cancer prognoses. MATERIAL AND METHODS SOX7 mRNA expression in breast cancer tissues samples and matched adjacent normal controls of breast cancer patients was measured by quantitative real-time-polymerase chain reaction (qRT-PCR). The relationship of SOX7 with clinicopathological characteristics w...
CONCLUSIONS These 7 DEGs might be potential diagnostic and prognostic biomarkers for PAC and help uncovering the mechanism of PAC. PMID: 32235821 [PubMed - in process]
CONCLUSION: The prodromal symptoms of COVID-19 were mild and most patients did not have limitations of daily activity. Viral shedding from URT was high from the prodromal phase. Radiological pneumonia was common from the early days of illness, but it was frequently not evident in simple CXR. These findings could be plausible explanations for the easy and rapid spread of SARS-CoV-2 in the community. PMID: 32242348 [PubMed - in process]
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