Targeting Interleukin-1 β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling

TGF- β signaling has an unquestionable but still controversial role in the pathogenesis of aortic aneurysm. Da Ros et al. demonstrate that disruption of TGF-β signaling in SMCs activates an autocrine IL-1β pathway that acts as a danger signal to recruit innate immune cells in the adventitia through C CL2.

Source: Immunity - November 14, 2017 Category: Allergy & Immunology Authors: Francesco Da Ros, Raimondo Carnevale, Giuseppe Cifelli, Dario Bizzotto, Manuel Casaburo, Marialuisa Perrotta, Lorenzo Carnevale, Iolanda Vinciguerra, Stefania Fardella, Roberta Iacobucci, Giorgio M. Bressan, Paola Braghetta, Giuseppe Lembo, Daniela Carnev Tags: Article Source Type: research