Controlling miRNA-like Off-target Effects of an siRNA with Nucleobase Modifications

Org. Biomol. Chem., 2017, Accepted Manuscript DOI: 10.1039/C7OB02654D, PaperScott Ryan Suter, Alexi A Ball-Jones, Madeline M. Mumbleau, Rachel Valenzuela, Jose M. Ibarra-Soza, Hassan Owens, Andrew Fisher, Peter A Beal SiRNAs can cause unintended gene silencing due to miRNA-like effects because of the similarity in function of an siRNA guide strand and a miRNA. Here we evaluate the effect on... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - November 14, 2017 Category: Molecular Biology Authors: Scott Ryan Suter Source Type: research