Are Double-Lung Transplants From Older Donors Reasonable? Are Double-Lung Transplants From Older Donors Reasonable?
Transplanting older donor lungs into younger patients may result in'reasonable outcomes,'but mainly for double lung transplants, according to an analysis of younger recipients.Reuters Health Information
In this prospective, single-center, observational study, we sought to investigate the association between repeated short periods of circulatory arrests with moderate hypothermia during pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and different neuropsychological dimensions.
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This study aimed to describe recipients ’ characteristics, and the frequency and etiology of infections and transplant outcome in liver and lung SOTs, and to investigate exposures associated to infection and death in liver transplant recipients. The study population included recipients of SOTs performed in Italy during a 1-year period i n ten Italian lung transplant units and eight liver transplant units. Data on comorbidities, infections, retransplantation, and death were prospectively collected using a web-based system, with a 6-month follow-up. The cumulative incidence of infection was 31.7% and 47.8% in liver and...
No abstract available
Short-term outcomes of solid organ transplantation have improved dramatically over the past several decades; however, long-term survival has remained static over the same period, and chronic rejection remains a major cause of graft failure. The importance of donor, or “passenger,” lymphocytes to the induction of tolerance to allografts was recognized in the 1990s, but their precise contribution to graft acceptance or rejection has not been elucidated. Recently, specialized populations of tissue-resident lymphocytes in nonlymphoid organs have been described. These lymphocytes include tissue-resident memory T cel...
Conclusions Induction with sc28AT promotes early cardiac allograft protection in hu5C8-treated NHPs. These results support further investigation of prolonged selective CD28 inhibition with CD40/CD154 blockade in NHP transplants.
Conclusions Less invasive retransplantation of the lung via sternum-sparing anterolateral thoracotomies and off-pump is a safe procedure with low associated morbidity and favorable midterm survival.
Heart failure results in significant morbidity and mortality for young children with hypoplastic left heart syndrome (HLHS) following the Norwood procedure.
Incompatibility to HLA antigens was the sentinel barrier which historically limited solid organ transplantation. The development of the complement dependent cytotoxicity (CDC) assay by Terasaki half a century ago allowed estimation of rejection risk at transplantation.1 Subsequent emergence of effective immunosuppressive regimens led to significant expansion of transplantation as a suitable therapeutic option for end-stage organ disease. In heart transplantation, the resulting improvement in outcomes has led to a corresponding broadening of the indications for transplant.
The optimal strategy for prevention of invasive fungal infections in lung transplant recipients remains undetermined. We studied a bronchoalveolar lavage fungal culture and galactomannan based strategy for prevention of invasive aspergillosis in lung transplant recipients