A Phase II Trial of Ruxolitinib in Combination with Azacytidine in Myelodysplastic Syndrome/Myeloproliferative Neoplasms

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Source: American Journal of Hematology - Category: Hematology Authors: Tags: Research Article Source Type: research

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Thread Starter Will voluntary detainment in a mental hospital affect becoming a medic? Follow 30 minutes ago 30m ago I haven’t been hospitalised but I have overdosed. As others have said it’s confidential and won’t affect you application or acceptance so that shouldn’t stop you fr...
Source: The Student Room - Category: Universities & Medical Training Authors: Tags: Medicine Source Type: forums
Conditions:   Beta Thalassemia Major Anemia;   Iron Overload Interventions:   Drug: Deferiprone oral solution;   Drug: Placebo Sponsor:   ApoPharma Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Iron Deficiency Anemia Interventions:   Drug: Ferric carboxymaltose;   Drug: Iron sucrose Sponsors:   Vifor Inc.;   Tigermed Consulting Co., Ltd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Mirza FG, Kadir RA, Breymann C, Fraser IS, Taher A Abstract INTRODUCTION: Iron deficiency and iron deficiency anemia are highly prevalent among women throughout their lives. Some females are particularly vulnerable to iron deficiency/iron deficiency anemia, including those with heavy menstrual bleeding and pregnant/postpartum women. Despite the high prevalence of iron deficiency/iron deficiency anemia in women, the condition is still underdiagnosed, and therefore undertreated, with serious clinical consequences. Areas covered: The following review examines the impact of iron deficiency and iron deficiency ...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
This report provides new information on the effect of vanadate and magnesium and their interactions on some oxidative stress markers and level of selected elements in rat RBCs.
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
BACKGROUND: Musculoskeletal involvement and cerebrovascular disease are common in sickle cell anaemia (SCA). These changes are potentially important factors that modify the control of balance in this population. OBJECTIVE: To assess balance control...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
We present a 2-year-old boy with splenomegaly, leukocytosis, thrombocytopenia, anemia, and excess myeloblasts with easily seen Auer rods, and marked dysgranulopoiesis and dyserythropoiesis. Conventional cytogenetic analysis showed a sole abnormality of t(3;5)(q25;q35). Microarray analysis showed a terminal 21 Mb region of copy-neutral loss of heterozygosity on 19q. Disease-related somatic NRAS mutation was detected. This case represents an unusual JMML with Auer rods and marked myelodysplasia. These unusual histopathologic features may be related to the t(3;5)(q25;q35). A t(3;5) with variable breakpoints has been reported ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
We report the extraordinary case of a patient with MDS who developed T‐LGLL, and subsequently the MDS progressed to CMML. The patient then developed diffuse arthropod bite‐like papules and intractable pruritus.
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Concise Report Source Type: research
We present a 2-year-old boy with splenomegaly, leukocytosis, thrombocytopenia, anemia, and excess myeloblasts with easily seen Auer rods, and marked dysgranulopoiesis and dyserythropoiesis. Conventional cytogenetic analysis showed a sole abnormality of t(3;5)(q25;q35). Microarray analysis showed a terminal 21 Mb region of copy-neutral loss of heterozygosity on 19q. Disease-related somatic NRAS mutation was detected. This case represents an unusual JMML with Auer rods and marked myelodysplasia. These unusual histopathologic features may be related to the t(3;5)(q25;q35). A t(3;5) with variable breakpoints has been reported ...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
GATA family proteins play essential roles in development of many cell types, including hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3, are essential for normal hematopoiesis, and their mutations are responsible for a variety of blood disorders. Acquired and inherited GATA1 mutations contribute to Diamond-Blackfan anemia, acute megakaryoblastic leukemia, transient myeloproliferative disorder, and a group of related congenital dyserythropoietic anemias with thrombocytopenia. Conversely, germ line mutations in GATA2 are associated with GATA2 deficiency syndrome, whereas acquired mu...
Source: Blood - Category: Hematology Authors: Tags: Hematopoiesis and Stem Cells, Pediatric Hematology, Free Research Articles, Myeloid Neoplasia, Phagocytes, Granulocytes, and Myelopoiesis, Red Cells, Iron, and Erythropoiesis, Review Articles, Review Series Source Type: research
More News: Anemia | Hematology | Myelodysplastic Syndrome | Myeloproliferative Disorders | Thrombocytopenia