DAPT score – Dual Antiplatelet Therapy Score

DAPT score (Dual Antiplatelet Therapy Score) was developed to dichotomize patients after percutaneous coronary intervention [PCI] into those who will benefit from prolonged DAPT (score 2 or more) and those who are more likely to be harmed by DAPT (score less than 2). A recent study evaluated DAPT with aspirin and clopidogrel given for 2 years vs 6 months in 1970 patients undergoing PCI [1]. Primary efficacy outcomes were death, myocardial infarction or cerebrovascular accident. Primary safety outcome was significant bleeding. In this retrospective study they concluded that prolonged DAPT resulted in harm in patients with low DAPT scores, but reduced ischemic events in those with high scores. DAPT score is calculated as follows: Age 75 years or more: -2, age 65 – 75 years: -1, age below 65 years: 0, current smoker, diabetes mellitus, myocardial infarction (MI) at presentation, prior PCI or MI, stent diameter less than 3 mm and paclitaxel-eluting stent – 1 each, congestive heart failure or left ventricular ejection fraction less than 30% and saphenous vein graft PCI 2 each [2]. Total score can range from -2 to 10 points. The score was developed using the data from nearly 12 thousand participants of DAPT study from 11 countries and validated using data from PROTECT trial which had over 8100 patients from 36 countries. Score below 2 is associated with unfavourable benefit/risk ration for prolonged dual antiplatelet therapy while scores of 2 and above have a favourabl...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs