DAPT score – Dual Antiplatelet Therapy Score

DAPT score (Dual Antiplatelet Therapy Score) was developed to dichotomize patients after percutaneous coronary intervention [PCI] into those who will benefit from prolonged DAPT (score 2 or more) and those who are more likely to be harmed by DAPT (score less than 2). A recent study evaluated DAPT with aspirin and clopidogrel given for 2 years vs 6 months in 1970 patients undergoing PCI [1]. Primary efficacy outcomes were death, myocardial infarction or cerebrovascular accident. Primary safety outcome was significant bleeding. In this retrospective study they concluded that prolonged DAPT resulted in harm in patients with low DAPT scores, but reduced ischemic events in those with high scores. DAPT score is calculated as follows: Age 75 years or more: -2, age 65 – 75 years: -1, age below 65 years: 0, current smoker, diabetes mellitus, myocardial infarction (MI) at presentation, prior PCI or MI, stent diameter less than 3 mm and paclitaxel-eluting stent – 1 each, congestive heart failure or left ventricular ejection fraction less than 30% and saphenous vein graft PCI 2 each [2]. Total score can range from -2 to 10 points. The score was developed using the data from nearly 12 thousand participants of DAPT study from 11 countries and validated using data from PROTECT trial which had over 8100 patients from 36 countries. Score below 2 is associated with unfavourable benefit/risk ration for prolonged dual antiplatelet therapy while scores of 2 and above have a favourabl...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: General Cardiology Source Type: blogs

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ConclusionThe findings from this study have established the need to improve current education and rehabilitation programmes for patients with CHF by addressing those factors significantly influencing their adherence to diet and medication.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
DiscussionHyperchloremic acidosis is associated with a non-anion gap, decrease in plasma bicarbonate and increase in plasma chloride. Rarely, as with this case, it may present with a high-anion gap. The use of bicarbonate therapy has shown improvement in cases of non-anion gap acidosis however there is very little data to support its role in high-anion gap hyperchloremic metabolic acidosis.
Source: African Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
This study aimed to investigate the mechanism of action of ginger extract and its compound, 6-shogaol, on pancreatic islets as well as on expressions of TRPV-1 and NMDAR2B in the spinal cord of streptozotocin (STZ)-induced mice model of PDN.Materials and methodsSixty-four 5–6 months old male-Balb/C mice were induced with 110 mg/kgBW STZ i.p., while eight mice were used as control group. Mice with blood glucose level ≥200 mg/d, that suffered hyperalgesia and allodynia were classified as PDN mice. Hot plate and von Frey filament tests were performed once a week until termination. At day 28 after considered as PDN,...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionThe authors recommended short implants whenever the height of available bone permits optimum implant placement. The authors concluded that both treatment options are considered viable clinically and radiographically. However, short implants have shown reduced postoperative discomfort, minimal invasiveness, and reduced cost.
Source: Journal of Evidence Based Dental Practice - Category: Dentistry Source Type: research
Publication date: Available online 16 November 2019Source: EXPLOREAuthor(s): N. Mangaiarkarasi, C. Senthilkumar, N. Manavalan, A. MooventhanAbstractA 75-year-old, married man was diagnosed with coronary artery disease (CAD) [severe triple vessel disease (TVD)] in the 2nd week, June-2018. The physician advised him to undergo conventional medication and coronary artery bypass graft. Since the patient refused to undergo surgery he was admitted in our hospital and underwent yoga and naturopathy-based lifestyle modification (YNLM) along with conventional medicines for 16 weeks [12 weeks of intensive care at inpatient department...
Source: EXPLORE: The Journal of Science and Healing - Category: Complementary Medicine Source Type: research
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Source: AARP.org News - Category: American Health Source Type: news
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Source: AARP.org News - Category: American Health Source Type: news
Taking blood pressure pills at the right time halves the risk of heart failure, heart attack and stroke. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Blood Pressure Source Type: blogs
Confabulation of a confused cardiologist Yes, It has never bothered me to retrogradely cross a delicately dangerous epicardial collateral in complex CTO. Delivering a twin stent in a partial culotte strategy for a bifurc lesion has never tested my talents. Stenting a left main across the LAD, jailing the LCX with OCT support is my favorite time pass. Crushing a calcium infested diffuse long lesion with diamond-tipped ablator appear as breezy as shopping in a mall. Oh …I am terribly upset with this damn thing.  What is that? It requires 4 negative forces . . . to bring one big positive Impact! These studies say ...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: acute coronary syndrome acc esc guidelines scai pci ptca stable chd courage bari 2d orbita ischemia trials tips and tricks in ptca Source Type: blogs
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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