Virulent gene profile and antimicrobial susceptibility pattern of Shiga toxin-producing Escherichia coli (STEC) from humans in Maiduguri, Borno State, North-Eastern Nigeria

AbstractPrevalence and distribution of Shiga toxin-producingEscherichia coli (STEC) serogroups majorly linked with public health hazards in Maiduguri and the antimicrobial resistance pattern profile of the isolates were determined. Our results show that the prevalence of STEC isolated from human patients with gastroenteritis attending hospitals in Maiduguri was 1.2% of the 600 stool specimens examined. Two patients out of the seven STEC positive isolates had diarrhoea, and no significant statistical association (P 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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The World Health Organization Supranational TB Reference Laboratory Network (SRLN) has served as the backbone for TB drug-resistance surveillance and diagnosis since 1994 and remains a key WHO programme for antimicrobial resistance (AMR) surveillance at the global level. SRLN is a great technical resource for proficiency testing to ensure accuracy of drug-susceptibility testing, scale-up, capacity development in countries and provides unique support to the reliable detection of drug resistance. Technical assistance from individual SRLs has been supported by a variety of mechanisms but funding for the SRLN has become increasingly challenging.
Source: Clinics in Chest Medicine - Category: Respiratory Medicine Authors: Source Type: research
Publication date: Available online 11 November 2019Source: The LancetAuthor(s): Stephen A Harrison, Mustafa R Bashir, Cynthia D Guy, Rong Zhou, Cynthia A Moylan, Juan P Frias, Naim Alkhouri, Meena B Bansal, Seth Baum, Brent A Neuschwander-Tetri, Rebecca Taub, Sam E MoussaSummaryBackgroundNon-alcoholic steatohepatitis (NASH) is characterised by hepatic steatosis, inflammation, hepatocellular injury, and progressive liver fibrosis. Resmetirom (MGL-3196) is a liver-directed, orally active, selective thyroid hormone receptor-β agonist designed to improve NASH by increasing hepatic fat metabolism and reducing lipotoxicity....
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionESBL/AmpC-E. coli colonized the gut of travelers to Vietnam with a CTX-resistant E. coli (>107 CFU/g feces), and the colonization lasted 14 weeks.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsThe findings of this study will contribute to the design of appropriate interventions, based on local evidence, for the establishment of antimicrobial stewardship programs in a country characterized by excessive use of antimicrobials and high resistance rates.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 11 November 2019Source: Journal of Global Antimicrobial ResistanceAuthor(s): Jayalaxmi Wangkheimayum, Trisha Datta Majumder, Yasmin Begam Tapadar, Bhaskar Jyoti Das, Deepjyoti Paul, Debadatta Dhar, Atanu Chakravarty, Amitabha Bhattacharjee
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
The quorum sensing (QS) system controls bacterial biofilm formation, which is highly related to the virulence and resistance of pathogens. In the present study, the effect of two traditional Chinese medicine (TCM) monomers, berberine and matrine, on biofilm formation and QS-related gene expression of antimicrobial-resistant (AMR) Escherichia coli strains was investigated by laser scanning confocal microscopy (LSCM) observation and real-time PCR. The results indicated a roughly positive relationship between biofilm formation ability and antimicrobial resistance. LSCM observation showed that berberine and matrine inhibited b...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: İşeri Nepesov M, Dinleyici M, Kılıç Ö, Ceyhan M, Gürler N, Dinleyici EÇ Abstract Streptococcus pneumoniae is a major cause of bacterial meningitis in children. It can progress and carries a serious risk of mortality and morbidity despite effective treatment. Cochlear implantation is a fairly successful procedure for restoring hearing in cases of sensorineural hearing loss. Moreover, patients with cochlear implants are at increased risk of contracting pneumococcal meningitis compared to the general population. The development of meningitis is associated with pathogens in the midd...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
In conclusion, we emphasize that it is of importance to work closely with the hospital administration to take measures and that necessary assistance is provided. PMID: 31709934 [PubMed - in process]
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
CONCLUSION: In southern China, the proportion of ESBL-producing strains and the drug resistance rates of E. coli and K. pneumoniae in UTI in children was high, but their resistance rates to carbapenems and β-lactamase inhibitor complexes containing tazobactam were low. Carbapenems are the most effective antibacterial drugs for the treatment of ESBL-producing bacteria. PMID: 31707407 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
Publication date: Available online 11 November 2019Source: Preventive Veterinary MedicineAuthor(s): V. Fruscalso, G. Olmos, M.J. HötzelAbstractOur retrospective, cross-sectional study aimed to identify the mortality rate of preweaned heifer calves and associated herd-management factors in family-run dairy holdings in the state of Rio Grande do Sul, Brazil. A survey was made available through an online platform to all the municipalities (n = 494) with a state official extension office (Emater), allowing for any milk producer in RS raising the calves on-farm to take part in the study. A total of 1,451 fram...
Source: Preventive Veterinary Medicine - Category: Veterinary Research Source Type: research
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