Effects of dark chocolate on endothelial function in patients with non-alcoholic steatohepatitis

Oxidative stress plays a pivotal role in inducing endothelial dysfunction and progression from simple fatty liver steatosis (FLD) to non-alcoholic steatohepatitis (NASH). Polyphenols could reduce oxidative stress and restore endothelial function by inhibiting the nicotinamide-adenine-dinucleotide-phosphate (NADPH) oxidase isoform Nox2.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research

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Publication date: Available online 12 December 2019Source: Prostaglandins &Other Lipid MediatorsAuthor(s): Rodolfo Quintana Castro, Isaac Aguirre Maldonado, Ida Soto Rodríguez, Rosa A. Deschamps Lago, Peter Grube Pagola, Yolanda K. Urbina de Larrea, Victoria E. Juárez Rivera, Luis E. Ramos Manuel, Alfonso Alexander AguileraAbstractObesity is considered a global epidemic and is mainly associated with the development of diabetes, cardiovascular diseases and Non-Alcoholic Fatty Liver (NAFLD). The pathogenesis between obesity and hepatic steatosis is partially known, but could involve differentiated or tissue...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Publication date: Available online 13 December 2019Source: Food ChemistryAuthor(s): Yifan Bao, Jianbo Xiao, Zebin Weng, Xinyi Lu, Xinchun Shen, Fang WangAbstractThe increasing incidence of metabolic syndrome requires more functional food products with low cost and excellent effects to assist treatment. The crude extract of Moringa oleifera Lam. showed excellent hypoglycemic activity. The current study was designed to investigate the effects and mechanism of niazirin, a bioactive component from Moringa oleifera Lam. seed, on diabetic metabolic syndrome. C57BL/6J mice were treated daily with 5 mL/kg/body weight (BW) of salin...
Source: Food Chemistry - Category: Food Science Source Type: research
This study aimed to assess the association between serum ferritin (SF) and NAFLD among middle-aged and elderly Chinese with normal weight. METHODS AND STUDY DESIGN: A total of 2029 Chinese adults aged 35-70 years with normal weight were involved in this cross-sectional study. General information, lifestyle factors and laboratory characteristics were collected. The concentrations of serum alanine aminotransferase (ALT) and SF were recorded. Receiver operating characteristic (ROC) was applied to assess predictive performance of SF for NAFLD. Logistic regression analysis was conducted to evaluate the associations of SF w...
Source: Asia Pacific Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Asia Pac J Clin Nutr Source Type: research
Obesity is a prevalent predisposing factor to non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the developed world. NAFLD spectrum of disease involves progression from steatosis (NAFL), to steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). Despite clinical and public health significance, current FDA approved therapies for NAFLD are lacking in part due to insufficient understanding of pathogenic mechanisms driving disease progression. The etiology of NAFLD is multifactorial. The induction of both systemic and tissue inflammation consequential of skewed immune cell metabo...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Cardiometabolic diseases encompass those affecting the heart and vasculature as well as other metabolic problems, such as insulin resistance, diabetes, and non-alcoholic fatty liver disease. These diseases tend to have common risk factors, one of which is impaired adiponectin action. This may be due to reduced bioavailability of the hormone or resistance to its effects on target tissues. A strong negative correlation between adiponectin levels and cardiometabolic diseases has been well-documented and research shown that adiponectin has cardioprotective, insulin sensitizing and direct beneficial metabolic effects. Thus, the...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Blood alcohol levels, also known as blood alcohol content, is a way to measure an individual’s level of alcohol intoxication. It represents the percentage of alcohol that is concentrated in the bloodstream. Blood alcohol levels are used for legal purposes, such as measuring individuals for drunk driving incidents, and for medical purposes, such as testing patients who enter the hospital for alcohol-related health issues. What Are The Different Blood Alcohol Levels? There are many factors that influence a person’s blood alcohol levels. They can include body weight, gender, genetics, tolerance to alcohol, drinki...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Alcohol Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility alcohol use Alcoholics Anonymous Source Type: blogs
Authors: Mirhafez SR, Rezai A, Dehabeh M, Nobakht M Gh BF, Bidkhori M, Sahebkar A, Hariri M Abstract Scientists proposed that curcumin could be used for treatment of non-alcoholic fatty liver disease (NAFLD). In this article, we aimed to identify the effect of curcumin on NAFLD improvement. Fifty patients with NAFLD, were divided into two groups in this randomized, double-blind, and controlled clinical trial. Patients in the curcumin group received 250 mg/day of phytosomal curcumin, while those in the control group received 250 mg/day of placebo for duration of eight weeks. Anthropometric measurements an...
Source: International Journal for Vitamin and Nutrition Research - Category: Nutrition Tags: Int J Vitam Nutr Res Source Type: research
Condition:   NAFLD Interventions:   Drug: Saroglitazar;   Drug: Vitamin E;   Drug: Combination drug;   Behavioral: Lifestyle Changes Sponsor:   Asian Institute of Gastroenterology, India Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractNon-alcoholic fatty liver disease (NAFLD) is the well-known disease of the liver in adults and children throughout the world. The main manifestations related to NAFLD are an unusual storage of lipid in hepatocytes (hepatic steatosis) and progression of inflammation for non-alcoholic steatohepatitis (NASH). NAFLD is described as a multifactorial complication due to the genetic predisposition, metabolic functions, inflammatory, gut microbiota (GM), and environmental factors. The GM dysregulation among these factors is correlated to NAFLD development. In recent decades, advanced microbial profiling methods are continu...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Conditions:   Non-Alcoholic Fatty Liver Disease;   Non-alcoholic Fatty Liver;   Non-alcoholic Steatohepatitis Intervention:   Sponsors:   Cambridge University Hospitals NHS Foundation Trust;   The European Association for the Study of the Liver;   Children's Liver Disease Foundation Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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