Letter re: Effects of orthostatic hypotension on cognition in Parkinson disease

We read with interest the article by Centi et al.,1 which investigated the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in 18 patients with idiopathic Parkinson disease (PD) with OH (PDOH) and 19 patients with PD without OH and 18 controls.1 The authors demonstrated that, during upright posture, PDOH exhibited a transient wider range of deficits in executive function, memory, and visuospatial function in excess of those found in PD without OH.
Source: Neurology - Category: Neurology Authors: Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

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19 –22 August 2018, Lyon, France
Source: Scientific and Medical Events on Global Events List - Category: Science Source Type: events
This study examines the therapeutic effects of transplantation of Nurr1 gene-modified bone marrow mesenchymal stem cells (MSCs) on 6-hydroxydopamine (6-OHDA)-induced PD rat models. MSCs were transduced with lentivirus expressing Nurr1 gene and then intrastriatally transplanted into PD rats. Our results showed that Nurr1 gene-modified MSCs overexpress and secrete Nurr1 protein in vitro and also survive and migrate in the brain. Four weeks after transplantation Nurr1 gene-modified MSCs dramatically ameliorated the abnormal behavior of PD rats and increased the numbers of tyrosine hydroxylase (TH)-positive cells in the substa...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
ConclusionsWe concluded that cognitive training along with active tDCS is a useful combined approach in the management of mood and cognitive dysfunctions in PD.
Source: Brain Stimulation - Category: Neurology Source Type: research
Bacteriophages could be the previously overlooked trigger for this movement disorder, which is growing in incidence.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
ConclusionOur studies demonstrate that VPA exerts neuroprotective effects in a rat model of 6-OHDA-induced Parkinson's disease (PD), likely in part by up-regulation BDNF.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
Our earliest memory can shape our lives, but new research suggests that many are false. Here, writers and readers reflect on their earliest recollectionsIt starts as a dreamy state of dizzying vertigo, and then I rattle, headfirst, down the wooden stairs. Falling down the white-painted (I think), definitely uncarpeted stairs of our first house is my first memory, and I must have been around two. But is it real? A new study suggests not, and if you can remember lying in your pram/taking your first steps/having your nappy changed, then you are almost certainly wrong, too.In a survey of more than 6,600 people, published in Ps...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Memory Science Source Type: news
ConclusionsCognitive impairments were common in PD patients even in the absence of dementia. PD patients with anti-parkinsonian medication had worse cognitive impairment than untreated patients. Genders may have different manifestations of cognitive impairment in PD patients.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
by Malbor Asllani, Paul Expert, Timoteo Carletti Many collective phenomena in Nature emerge from the -partial- synchronisation of the units comprising a system. In the case of the brain, this self-organised process allows groups of neurons to fire in highly intricate partially synchronised patterns and eventually lead to high level cognitive out puts and control over the human body. However, when the synchronisation patterns are altered and hypersynchronisation occurs, undesirable effects can occur. This is particularly striking and well documented in the case of epileptic seizures and tremors in neurodegenerative disease...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
ConclusionLate levodopa administration was associated with a low risk of dyskinesia after adjusting for confounding effects and may be a reasonable strategy for prolonging the levodopa-induced dyskinesia-free period in Parkinson ’s disease.
Source: CNS Drugs - Category: Neurology Source Type: research
AbstractParkinson ’s disease is the second most common neurodegenerative disorder. It is characterised by a typical movement disorder that occurs in part because of the selective degeneration of the dopaminergic neurons of the substantia nigra pars compacta. Current treatment for the motor disorder of Parkinson’s disease consists of dopaminergic medications, but these come with significant adverse effects, themselves an important part of the clinical course of Parkinson’s disease, particularly in advanced stages. Therefore, treatment is needed that can restore dopaminergic tone in the striatum in a physio...
Source: BioDrugs - Category: Drugs & Pharmacology Source Type: research
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