Letter re: Effects of orthostatic hypotension on cognition in Parkinson disease
We read with interest the article by Centi et al.,1 which investigated the relation between orthostatic hypotension (OH) and posture-mediated cognitive impairment in 18 patients with idiopathic Parkinson disease (PD) with OH (PDOH) and 19 patients with PD without OH and 18 controls.1 The authors demonstrated that, during upright posture, PDOH exhibited a transient wider range of deficits in executive function, memory, and visuospatial function in excess of those found in PD without OH.
Conditions: Pain; Parkinson Disease Interventions: Device: deep rTMS; Device: placebo deep rTMS Sponsor: University of Sao Paulo Recruiting
Conclusion: A machine learning method for automated analysis of data from the Noldus Catwalk system was established. Significance: Our works shows the ability of machine learning to discriminate pharmacologically relevant animal groups based on their walking behavior in a multivariate manner. Further interesting aspects of the approach include the ability to learn from past experiments, improve with more data arriving and to make predictions for single animals in future studies.
This article reviews recent studies at ultra-high field about Alzheimer’s disease (AD), Park inson’s disease (PD), and amyotrophic lateral sclerosis (ALS).Recent FindingsThe research on AD has mainly focused on detecting the thinning of hippocampal layers and the susceptibility effect supposed to be related to beta-amyloid deposition. In patients with PD, atypical parkinsonisms and subjects at risk of developing motor symptoms of Parkinson ’s disease, the main aim was to detect changes in the substantia nigra, probably related to increased iron deposition. In patients with ALS, both brain and spinal cord ...
Even a mild brain injury may significantly increase risk, according to a new large study of U.S. veterans
CONCLUSIONS: The TUG, FTSTS and BMT were responsive to the GPTI and accurately detected meaningful clinical changes. Our results provide an important information about the clinical application of these tests in PD individuals. PMID: 29660960 [PubMed - as supplied by publisher]
CONCLUSION: The present findings demonstrate that gait training with a VR program is as effective as treadmill training with regard to gains in walking distance and improvements in temporal gait variables in individuals with PD. PMID: 29660956 [PubMed - as supplied by publisher]
CONCLUSIONS: We demonstrated that neuromuscular electrical stimulation applied to the infrahyoid region combined with effortful swallowing effectively increased hyoid bone movement and reduced aspiration in dysphagic patients with Parkinson's disease. PMID: 29660951 [PubMed - as supplied by publisher]
Authors: Gallastegui E, Domuro C, Serratosa J, Larrieux A, Sin L, Martinez J, Besson A, Morante-Redolat JM, Orlando S, Aligue R, Fariñas I, Pujol MJ, Bachs O Abstract Alpha-synuclein (α-SYN) is the main component of anomalous protein aggregates (Lewy bodies) that play a crucial role in several neurodegenerative diseases (synucleinopathies) like Parkinson's disease and multiple system atrophy. However, the mechanisms involved in its transcriptional regulation are poorly understood. We investigated here the role of the cyclin-dependent kinase (Cdk) inhibitor and transcriptional regulator p27Kip1 (p27) in...
(Reuters Health) - A new study of hundreds of thousands of U.S. armed forces veterans concludes that banging your head severely enough to lose consciousness can dramatically increase the risk of Parkinson's, the brain disease marked by tremors, slow movements, balance problems and difficulty walking.
OBJECTIVE: Excessive daytime sleepiness (EDS) is one of the most common sleep abnormalities in patients with Parkinson's disease (PD), yet its multifactorial etiology complicates its treatment. This review summarized recent studies on the epidemiology, eti...