Author response: Risks and benefits of clopidogrel-aspirin in minor stroke or TIA: Time course analysis of CHANCE

We appreciate Drs. Gutierrez and Lekic's emphasis on the time-course analysis of dual antiplatelet therapy (DAPT) by intracranial arterial stenosis (ICAS) in their comments on our article.1 Only 1,089 patients were included in the imaging substudy.2 In patients with ICAS, 19 (8.2%), 3 (1.3%), and 0 ischemic strokes in the DAPT group (n = 231) vs 25 (10.0%), 6 (2.4%), and 0 in the aspirin alone group (n = 250), and 4 (1.7%), 0, and 2 (0.9%) bleeding in the DAPT group vs 1 (0.4%), 0, and 0 in the aspirin alone group, occurred at the first, second, and third week, respectively. In patients without ICAS, 11 (3.7%), 1 (0.3%), and 0 ischemic strokes in the DAPT group (n = 300) vs 9 (2.9%), 1 (0.3%), and 2 (0.6%) in the aspirin alone group (n = 308), and 5 (1.7%), 0, and 0 bleeding in the DAPT group vs 4 (1.3%), 1 (0.3%), and 0 in the aspirin alone group, occurred at the first, second, and third week, respectively. The absolute risk reduction in ischemic stroke in the first 2 weeks was 2.9% with DAPT compared to aspirin alone in patients with ICAS and –0.8% among those without ICAS, compared with 3.2% (not 4.5%, which is the proportion of events occurred at each week among total events) in the total 5,170 patients in our article.1
Source: Neurology - Category: Neurology Authors: Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research