Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1).

CONCLUSION: Our results demonstrate that apigenin regulates OAT1, and can cause TDI or herb-drug interaction (HDI) when used in combination with acyclovir or adefovir. Therefore, apigenin could be used as a nephroprotective agent when used in combination with the substrates of OAT1. PMID: 29128807 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29128807?dopt=Abstract

Source: Pharmacological Reports - June 27, 2017 Category: Drugs & Pharmacology Authors: Wu T, Li H, Chen J, Cao Y, Fu W, Zhou P, Pang J Tags: Pharmacol Rep Source Type: research