A tiny tick can cause a big health problem

We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination. The ticks were firmly latched on to the skin and careful removal prevented incarceration of the mouth parts. Rickettsial diseases that were believed to have disappeared from India are reemerging and their presence has recently been documented in at least 11 states in the country. Among vector borne diseases, the most common, Lyme disease, also known as the great mimicker, can present with rheumatoid arthritis, fibromyalgia, depression, attention deficit hyperactivity disorder, multiple sclerosis, chronic fatigue syndrome, cardiac manifestations, encephalitis, and mental illness, to name some of the many associations. Common ocular symptoms and signs include conjunctivitis, keratitis, uveitis, and retinitis. Early detection and treatment of tick borne diseases is important to prevent multi system complications that can develop later in life.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research

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In this study, we employ Designer Receptor Exclusively Activated by Designer Drugs (DREADDs) together with the mouse 5-Choice Serial Reaction Time Task (5-CSRTT) to investigate the necessary roles of these catecholamines in ADHD-related behaviors, including attention, impulsivity, and motivation. By selective inhibition of tyrosine hydroxylase (TH)-positive VTA dopamine neurons expressing the Gi-coupled DREADD (hM4Di), we observed a marked impairment of effort-based motivation and subsequently speed and overall vigor of responding. At the highest clozapine N-oxide (CNO) dose tested (i.e. 2 mg/kg) to activate hM4Di, we de...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
The objectives of the current review are to comprehensively evaluate (1) the potential role of orexins in the pathophysiology of major depressive disorders (MDD) and (2) the orexin system as a novel target in the treatment of MDD. Dysfunction of the sleep-wake cycle is observed as a central feature of MDD pathophysiology. Orexin system disturbances produce sleep-wake dysfunction, as observed in MDD. Orexin antagonists have been shown to treat insomnia effectively without disrupting normal sleep architecture in both preclinical (e.g., animal models) and clinical studies. Orexin antagonists are generally safe, well-tolerated...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 18 December 2018Source: Physiology &BehaviorAuthor(s): Laura Schäfer, Linda Mehler, Antje Hähner, Ute Walliczek, Thomas Hummel, Ilona CroyAbstractOlfaction moderates human sexual experiences and smell disorder patients sometimes spontaneously complain about impairments in their sexual life. The aim of the present study was to systematically investigate the impact of olfactory dysfunction on sexual desire.We compared a sample of n = 100 (n = 52 women; aged 23–51 years, M = 40.1, SD = 8.2) outpatients with olfactory disorders to a sample of n = 51 h...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Publication date: Available online 17 December 2018Source: Physiology &BehaviorAuthor(s): Liat Shbiro, Danielle Hen-Shoval, Noa Hazut, Kayla Rapps, Shira Dar, Gil Zalsman, Raphael Mechoulam, Aron Weller, Gal ShovalAbstractThe current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar re...
Source: Physiology and Behavior - Category: Physiology Source Type: research
Firearm deaths, including suicides, have been rising. Adjusted for population, the gun death rate in 2017 was the highest since the mid-1990s.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Gun Control Firearms Suicides and Suicide Attempts Murders, Attempted Murders and Homicides Deaths (Fatalities) Law and Legislation Source Type: news
CONCLUSION: This study suggests that NaCl can aggravate arthritis by affecting Th17 differentiation. Accordingly, limiting salt intake may be helpful for treating inflammatory arthritis, such as RA. PMID: 30554495 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
In this study, a novel thermophilic bacterial strain was isolated from Tattapani hot spring located in the Chhattisgarh state of India. The laccase was produced via submerged fermentation and purified by ammonium sulfate precipitation and anion exchange chromatography up to 13.7 fold. The 16S rRNA gene sequence and biochemical analysis revealed that the bacterial isolate is Bacillus sp. strain PC-3. The activity of extracellular crude laccase was determined to be 11.2 U/mL using 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid (ABTS) as a substrate. The SDS-PAGE revealed that the enzyme consists of single subu...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
Publication date: Available online 17 December 2018Source: Pharmacology Biochemistry and BehaviorAuthor(s): Miguel A. Lujan, Laura Colomar, Ernesto Tarragón, Laura López-Cruz, Raúl Pastor, Laura FontAbstractDrug-associated contexts and discrete cues can trigger motivational states responsible for drug-seeking behavior and relapse. In preclinical research, drug-free conditioned hyperactivity has been used to investigate the expression of memories associated with psychostimulant drug effects. Addictive drugs can produce long-lasting sensitization to their psychomotor actions, a phenomenon known as behavi...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
In this study, we examine the spatial localization of the various indole alkaloids in developing fruits and plants of R. tetraphylla using desorption electrospray ionization mass spectrometry imaging (DESI-MSI). A semi-quantitative analysis of the various indole alkaloids was performed using UPLC-ESI/MS. DESI-MS images showed that the distribution of ajmalcine, yohimbine, demethyl serpentine and mitoridine are largely localized in the fruit coat while that for ajmaline is restricted to mesocarp of the fruit. At a whole plant level, the ESI-MS intensities of many of the ions were highest in the roots and lesser in the shoot...
Source: Phytochemistry - Category: Chemistry Source Type: research
Allegheny Health Network and the Alexis Joy D ’Achille Foundation celebrated on Tuesday the grand opening of the Alexis Joy D’Achille Center for Perinatal Mental Health at West Penn Hospital, according to a statement. The new facility will provide women with pregnancy-related depression access to a number of care options while allowing the m to be with their infant. The 7,300-square-foot, $2.5 million facility includes rooms for individual therapy as well as space for Intensive Outpatient care,…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
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