A tiny tick can cause a big health problem

We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination. The ticks were firmly latched on to the skin and careful removal prevented incarceration of the mouth parts. Rickettsial diseases that were believed to have disappeared from India are reemerging and their presence has recently been documented in at least 11 states in the country. Among vector borne diseases, the most common, Lyme disease, also known as the great mimicker, can present with rheumatoid arthritis, fibromyalgia, depression, attention deficit hyperactivity disorder, multiple sclerosis, chronic fatigue syndrome, cardiac manifestations, encephalitis, and mental illness, to name some of the many associations. Common ocular symptoms and signs include conjunctivitis, keratitis, uveitis, and retinitis. Early detection and treatment of tick borne diseases is important to prevent multi system complications that can develop later in life.
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research

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This study investigated the effects of 12 wk of postexercise kefir consumption in cancer survivors who have undergone chemotherapy and/or radiation therapy. Methods All participants were enrolled in a structured exercise training program and separated into kefir (KEF) or control (CON) treatment groups. KEF consumed 8 oz. of kefir after exercise sessions (3 d·wk−1) for 12 wk. Outcome measures included assessments for body size and composition, aerobic fitness and muscular strength, medical history, and psychological state at pre- and postintervention time points. Blood was collected and analyzed for C-re...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Reuters: Health - Category: Consumer Health News Source Type: news
India News: Amid a decline in Covid cases in the country, India may soon reopen its doors for foreign tourists for the first time in...
Source: Reuters: Health - Category: Consumer Health News Source Type: news
Although intellectual disability was included in the first description of Duchenne muscular dystrophy (DMD), the cognitive and neurodevelopmental (ND) components of DMD and Becker muscular dystrophy (BMD) remain overshadowed by their motor, cardiac, and pulmonary manifestations. To assess the ND comorbidity burden in dystrophinopathy patients at Le Bonheur Children's Hospital neuromuscular clinic, abstraction of the electronic medical record was performed for 46 patients. Diagnoses of ADHD, epilepsy, autism spectrum, obsessive compulsive, oppositional defiant, mood, anxiety, and sleep disorders, along with discussion of an...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
The efficacy of avalglucosidase alfa compared to alglucosidase alfa as measured by the EuroQol 5-dimension 5-level (EQ-5D-5L) from the phase 3 COMET trial in late-onset Pompe disease (LOPD) is presented. EQ-5D-5L, a multi-attribute utility measure of health-related quality of life, was collected in treatment-na ïve LOPD patients. Change from baseline to week 49 in the five dimensions of EQ-5D-5L, including mobility, usual activities, self-care, pain/discomfort and anxiety/depression; the derived patient's health state/index (range: 0 to 1); and the visual analogue scale (VAS, self-rated health on a 0 [wor st health] t...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Patient report offers a simple and cost-effective means of identifying and tracking progression of oro-pharyngeal dysphagia (OPD) in degenerative conditions. Whilst validated patient-report tools have been developed for OPD in progressive conditions such as Multiple Sclerosis and Parkinson's Disease, the ability of individuals living with Myotonic Dystrophy Type 1 (DM1) to self-report signs and symptoms of their condition is not considered to be reliable. This leads to concerns about using patient-report to identify and manage OPD.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
This study evaluated the effects of the CYP2D6*10 and CYP2D6*5 genotypes on the steady-state plasma concentrations of VEN and ODV in Japanese patients. Methods: This study included 75 Japanese patients with depression who were treated with VEN. Steady-state plasma concentrations of VEN and ODV were measured using liquid chromatography. Polymerase chain reaction was used to determine CYP2D6 genotypes. A stepwise multiple regression analysis was performed to analyze the relationship between independent variables (sex, age, smoking habit, and number of mutated alleles, CYP2D6*10 and CYP2D6*5), subject-dependent variabl...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
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Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: Research Reports Source Type: research
Depression and anxiety are common neuropsychiatric disorders that usually appear as comorbidities. The development of new drugs is crucial for safer and more effective clinical management of both disorders. Riparin A is a synthetic chemical analog of riparins that naturally occur in several medicinal plants. Marked pharmacological effects such as anxiolytic and antidepressant properties characterize this class of compounds. However, little is known about the potential anxiolytic and antidepressant effects of Riparin A. In this work, we showed that, unlike other riparins, Riparin A exerts only a very mild anxiolytic-like ef...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: Research Articles Source Type: research
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