Cancers, Vol. 9, Pages 155: Current and Prospective Protein Biomarkers of Lung Cancer

Cancers, Vol. 9, Pages 155: Current and Prospective Protein Biomarkers of Lung Cancer Cancers doi: 10.3390/cancers9110155 Authors: Tatiana Zamay Galina Zamay Olga Kolovskaya Ruslan Zukov Marina Petrova Ana Gargaun Maxim Berezovski Anna Kichkailo Lung cancer is a malignant lung tumor with various histological variants that arise from different cell types, such as bronchial epithelium, bronchioles, alveoli, or bronchial mucous glands. The clinical course and treatment efficacy of lung cancer depends on the histological variant of the tumor. Therefore, accurate identification of the histological type of cancer and respective protein biomarkers is crucial for adequate therapy. Due to the great diversity in the molecular-biological features of lung cancer histological types, detection is impossible without knowledge of the nature and origin of malignant cells, which release certain protein biomarkers into the bloodstream. To date, different panels of biomarkers are used for screening. Unfortunately, a uniform serum biomarker composition capable of distinguishing lung cancer types is yet to be discovered. As such, histological analyses of tumor biopsies and immunohistochemistry are the most frequently used methods for establishing correct diagnoses. Here, we discuss the recent advances in conventional and prospective aptamer based strategies for biomarker discovery. Aptamers like artificial antibodies can serve as molecular recognition elements for isolation d...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research